More than a hundred genes have been identified that, when disrupted, impart large risk for
autism spectrum disorder (ASD). Current knowledge about the encoded proteins—although …

The neocortex is the seat of higher cognitive functions and, in evolutionary terms, is the
youngest part of the mammalian brain. Since its origin, the neocortex has expanded in …

INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities.
Variations in human cortical surface area and thickness are associated with neurological …

Human brain development exhibits several unique aspects, such as increased complexity
and expansion of neuronal output, that have proven difficult to study in model organisms. As …

The human cerebral cortex possesses distinct structural and functional features that are not
found in the lower species traditionally used to model brain development and disease …

Since the emergence of Zika virus (ZIKV), reports of microcephaly have increased
considerably in Brazil; however, causality between the viral epidemic and malformations in …

Zika virus (ZIKV) infection in utero might lead to microcephaly and other congenital defects.
Since no specific therapy is available thus far, there is an urgent need for the discovery of …

During vertebrate development, a wide variety of cell types and tissues emerge from a single
fertilized oocyte. One of these tissues, the central nervous system, contains many types of …

Neural circuit function can be drastically affected by variations in the number of cells that are
produced during development or by a reduction in adult cell number owing to disease. For …

Neural stem and progenitor cells have a central role in the development and evolution of the
mammalian neocortex. In this review, we first provide a set of criteria to classify the various …