Flavonoids, a series of compounds with a C6-C3-C6 structure, mostly originate from plant
metabolism. Flavonoids have shown beneficial effects on many aspects of human …

Mammalian carboxylesterases (CES), the key members of the serine hydrolase superfamily,
hydrolyze a wide range of endogenous substances and xenobiotics bearing ester or amide …

Abstract β-Glucuronidase plays a vital role in the metabolism of drugs and endogenous
substance. Herein, we assayed the inhibitory effects of thirty-six flavonoids (1–36) toward β …

Cyclophosphamide (CP) is commonly used as an anticancer agent but has been associated
with high toxicity in several animal organs, including the testes. Inositol hexaphosphate (IP6) …

The inhibition of soluble epoxide hydrolase (sEH) is a promising therapeutic approach to
treat inflammation and other disorders. In our present investigation on searching for sEH …

The roots of Euphorbia fischeriana known as “Langdu” in traditional Chinese medicine have
been used for the treatment of tuberculosis in China. Through a bioactive phytochemical …

As the primary enzyme responsible for the activatable conversion of Irinotecan (CPT-11) to
SN-38, carboxylesterase 2 (CES2) is a significant predictive biomarker toward CPT-11 …

Abstract Twenty-four new limonoids (1–24), named hainanxylogranins A–X, were isolated
from leaves and barks of the Hainan mangrove, Xylocarpus granatum, together with a …

Abstract Carboxylesterase 2 (CES 2), plays a pivotal role in endobiotic homeostasis and
xenobiotic metabolism. Protostanes, the major constituents of the genus Alisma, display a …

The phytochemical investigation of Andrographis paniculata resulted in the isolation of a
novel 15-spiro diterpenoid dimer bisandrographolide G (1). Its structure was determined by …