Asymmetric organocatalysis: an enabling technology for medicinal chemistry
B Han, XH He, YQ Liu, G He, C Peng… - Chemical Society Reviews, 2021 - pubs.rsc.org
The efficacy and synthetic versatility of asymmetric organocatalysis have contributed
enormously to the field of organic synthesis since the early 2000s. As asymmetric …
enormously to the field of organic synthesis since the early 2000s. As asymmetric …
Extracellular vesicles and particles impact the systemic landscape of cancer
Intercellular cross talk between cancer cells and stromal and immune cells is essential for
tumor progression and metastasis. Extracellular vesicles and particles (EVPs) are a …
tumor progression and metastasis. Extracellular vesicles and particles (EVPs) are a …
A comparative analysis of individual RAS mutations in cancer biology
C Muñoz-Maldonado, Y Zimmer, M Medová - Frontiers in oncology, 2019 - frontiersin.org
In human cells, three closely related RAS genes, termed HRAS, KRAS, and NRAS, encode
four highly homologous proteins. RAS proteins are small GTPases involved in a broad …
four highly homologous proteins. RAS proteins are small GTPases involved in a broad …
Targeting the ERK signaling pathway in melanoma
P Savoia, P Fava, F Casoni, O Cremona - International journal of …, 2019 - mdpi.com
The discovery of the role of the RAS/RAF/MEK/ERK pathway in melanomagenesis and its
progression have opened a new era in the treatment of this tumor. Vemurafenib was the first …
progression have opened a new era in the treatment of this tumor. Vemurafenib was the first …
RAS-mediated oncogenic signaling pathways in human malignancies
Abnormally activated RAS proteins are the main oncogenic driver that governs the
functioning of major signaling pathways involved in the initiation and development of human …
functioning of major signaling pathways involved in the initiation and development of human …
Targeting the small GTPase superfamily through their regulatory proteins
The Ras superfamily of small GTPases are guanine‐nucleotide‐dependent switches
essential for numerous cellular processes. Mutations or dysregulation of these proteins are …
essential for numerous cellular processes. Mutations or dysregulation of these proteins are …
[HTML][HTML] Emerging strategies for the improvement of chemotherapy in bladder cancer: Current knowledge and future perspectives
S Liu, X Chen, T Lin - Journal of advanced research, 2022 - Elsevier
Background Chemotherapy is a first-line treatment for advanced and metastatic bladder
cancer, but the unsatisfactory objective response rate to this treatment yields poor 5-year …
cancer, but the unsatisfactory objective response rate to this treatment yields poor 5-year …
Resistance to KRASG12C Inhibitors in Non-Small Cell Lung Cancer
JB Blaquier, AF Cardona, G Recondo - Frontiers in Oncology, 2021 - frontiersin.org
KRAS mutations are one of the most prevalent oncogenic alterations in cancer. Until
recently, drug development targeting KRAS did not convey clinical benefits to patients …
recently, drug development targeting KRAS did not convey clinical benefits to patients …
Surface molecules of extracellular vesicles secreted by the helminth pathogen Fasciola hepatica direct their internalisation by host cells
E de la Torre-Escudero, JQ Gerlach… - PLoS neglected …, 2019 - journals.plos.org
Helminth parasites secrete extracellular vesicles (EVs) that can be internalised by host
immune cells resulting in modulation of host immunity. While the molecular cargo of EVs …
immune cells resulting in modulation of host immunity. While the molecular cargo of EVs …
Targeting small GTPases: emerging grasps on previously untamable targets, pioneered by KRAS
G Yin, J Huang, J Petela, H Jiang, Y Zhang… - Signal transduction and …, 2023 - nature.com
Abstract Small GTPases including Ras, Rho, Rab, Arf, and Ran are omnipresent molecular
switches in regulating key cellular functions. Their dysregulation is a therapeutic target for …
switches in regulating key cellular functions. Their dysregulation is a therapeutic target for …