Objective: To update the 1994 practice parameter for the diagnosis of dementia in the
elderly. Background: The AAN previously published a practice parameter on dementia in …

As our society ages, age-related diseases assume increasing prominence as both personal
and public health concerns. Disorders of cognition are particularly important in both regards …

Astrocytes colocalize with fibrillar amyloid-β (Aβ) plaques in postmortem Alzheimer disease
(AD) brain tissue. It is therefore of great interest to develop a PET tracer for visualizing …

Background: Repetitive recall of traumatic memories and chronic intermittent hyperarousal
are characteristic of posttraumatic stress disorder (PTSD). Hyperarousal and memory …

A high percentage of patients with mild cognitive impairment (MCI) develop clinical
dementia of the Alzheimer type (AD) within 1 year. The aim of this longitudinal study was to …

After nearly a century of inquiry, the cause of Alzheimer's disease (AD) remains to be found.
In this review, basic and clinical evidence is presented that assembles and hypothetically …

To evaluate the utility of arterial spin‐labeled blood flow magnetic resonance imaging for the
detection of cerebral blood flow abnormalities in Alzheimer's disease, arterial spin‐labeled …

Frontotemporal dementia (FTD) and Alzheimer's disease are sometimes difficult to
differentiate clinically because of overlapping symptoms. Using diffusion tensor imaging …

Background ¹⁸F‐FDFG uptake by brain tissue as measured by positron emission
tomography (PET) is a well‐established method for assessment of brain function in people …

Studies in animals and postmortem human brain tissue support a role for P-glycoprotein in
clearance of cerebral β-amyloid across the blood–brain barrier (BBB). We tested the …