[HTML][HTML] Vaccines to prevent infectious diseases in the older population: immunological challenges and future perspectives

A Wagner, B Weinberger - Frontiers in immunology, 2020 - frontiersin.org
Infectious diseases are a major cause for morbidity and mortality in the older population.
Demographic changes will lead to increasing numbers of older persons over the next …

[HTML][HTML] Aging and options to halt declining immunity to virus infections

MÁ Palacios-Pedrero, ADME Osterhaus… - Frontiers in …, 2021 - frontiersin.org
Immunosenescence is a process associated with aging that leads to dysregulation of cells of
innate and adaptive immunity, which may become dysfunctional. Consequently, older adults …

[HTML][HTML] Safety, immunogenicity, and efficacy of a COVID-19 vaccine (NVX-CoV2373) co-administered with seasonal influenza vaccines: an exploratory substudy of a …

S Toback, E Galiza, C Cosgrove, J Galloway… - The Lancet …, 2022 - thelancet.com
Background The safety and immunogenicity profile of COVID-19 vaccines when
administered concomitantly with seasonal influenza vaccines have not yet been reported …

[HTML][HTML] Vaccination of older adults: Influenza, pneumococcal disease, herpes zoster, COVID-19 and beyond

B Weinberger - Immunity & Ageing, 2021 - Springer
Preserving good health in old age is of utmost importance to alleviate societal, economic
and health care-related challenges caused by an aging society. The prevalence and …

[HTML][HTML] Recent insight into SARS-CoV2 immunopathology and rationale for potential treatment and preventive strategies in COVID-19

S Lega, S Naviglio, S Volpi, A Tommasini - Vaccines, 2020 - mdpi.com
As the outbreak of the new coronavirus (SARS-CoV-2) infection is spreading globally, great
effort is being made to understand the disease pathogenesis and host factors that …

[HTML][HTML] A computationally optimized broadly reactive hemagglutinin vaccine elicits neutralizing antibodies against influenza B viruses from both lineages

MA Carlock, TM Ross - Scientific Reports, 2023 - nature.com
Influenza B viruses (IBV) can cause severe disease and death much like influenza A viruses
(IAV), with a disproportionate number of infections in children. Despite moving to a …

[HTML][HTML] IgA responses following recurrent influenza virus vaccination

RB Abreu, EF Clutter, S Attari, GA Sautto… - Frontiers in …, 2020 - frontiersin.org
Influenza is a highly contagious viral respiratory disease that affects millions of people
worldwide each year. Annual vaccination is recommended by the World Health Organization …

[HTML][HTML] Preexisting subtype immunodominance shapes memory B cell recall response to influenza vaccination

RB Abreu, GA Kirchenbaum, EF Clutter, GA Sautto… - JCI insight, 2020 - ncbi.nlm.nih.gov
Influenza is a highly contagious viral pathogen with more than 200,000 cases reported in the
United States during the 2017–2018 season. Annual vaccination is recommended by the …

[HTML][HTML] Impact of low rates of influenza on next-season influenza infections

MG Krauland, DD Galloway, JM Raviotta… - American Journal of …, 2022 - Elsevier
Introduction Interventions to curb the spread of COVID-19 during the 2020–2021 influenza
season essentially eliminated influenza during that season. Given waning antibody titers …

Immune imprinting in early life shapes cross-reactivity to influenza B virus haemagglutinin

P Edler, LSU Schwab, M Aban, M Wille… - Nature …, 2024 - nature.com
Influenza exposures early in life are believed to shape future susceptibility to influenza
infections by imprinting immunological biases that affect cross-reactivity to future influenza …