The flexibility of biomolecules enables them to adapt and transform as a result of signals
received from the external environment, expressing different functions in different contexts …

The search is on for effective specific inhibitors for PI3Kα mutants. PI3Kα, a critical lipid
kinase, has two subunits, catalytic and inhibitory. PIK3CA, the gene that encodes the p110α …

Macromolecular function frequently requires that proteins change conformation into high-
energy states,,–. However, methods for solving the structures of these functionally essential …

Allostery is a central mechanism for the regulation of multi-enzyme complexes. The
mechanistic basis that drives allosteric regulation is poorly understood but harbors key …

DNA switches are ideally suited for numerous nanotechnological applications, and
increasing efforts are being directed toward their engineering. In this review, we discuss how …

Historically, most drugs target protein orthosteric sites. The gradual emergence of resistance
hampers their therapeutic effectiveness, posing a challenge to drug development …

CRISPR–Cas9 is a widely employed genome-editing tool with functionality reliant on the
ability of the Cas9 endonuclease to introduce site-specific breaks in double-stranded DNA …

We report the construction of three structurally distinct self-assembled architectures:
FeII12L12 pseudoicosahedron 1, FeII2L3 helicate 2, and FeII4L4 tetrahedron 3, formed from …

G protein-coupled receptors (GPCRs), the largest family of human membrane proteins and
an important class of drug targets, play a role in maintaining numerous physiological …

Allosteric signaling in biological molecules, which may be viewed as specific action at a
distance due to localized perturbation upon binding of ligands or changes in environmental …