Chronic pain is a common, complex and unpleasant sensation following nerve injury, tissue
trauma, inflammatory diseases, infection and cancer. It affects up to 25% of adults and is …

Synapses serve as the interface for the transmission of information between neurons in the
central nervous system. The structural and functional characteristics of synapses are highly …

High endothelial venule protein/SPARC-like 1 (hevin/Sparcl1) is an astrocyte-secreted
protein that regulates synapse formation in the brain. Here we show that astrocytic hevin …

Remifentanil is a potent ultra-short acting μ-opioid analgesic drug, frequently used in
anaesthesia due to its favorable pharmacodynamic and pharmacokinetic profile. It may be …

摘要目的: 探究褪黑素通过改善神经元树突棘可塑性在瑞芬太尼诱发大鼠痛觉过敏机制中的作用
. 方法: 30 只8~ 10 周龄的SD 大鼠(175~ 200 g), 根据研究目的随机分为三组 …

Purpose: Neuropathic pain often originates from nerve injury or diseases of the
somatosensory nervous system. However, its specific pathogenesis remains unclear. The …

Hevin/Sparcl1 is an astrocyte-secreted protein and regulates synapse formation in the brain.
Here we show that astrocytic hevin signaling plays a critical role in maintaining chronic pain …