[HTML][HTML] Therapeutic potential of toosendanin: Novel applications of an old ascaris repellent as a drug candidate

M Hu, M Xu, Y Chen, Z Ye, S Zhu, J Cai… - Biomedicine & …, 2023 - Elsevier
Toosendanin (TSN), extracted from Melia. toosendan Sieb. et Zucc. and Melia. azedarach L.,
has been developed into an ascaris repellent in China. However, with the improvement of …

[HTML][HTML] Challenges and opportunities for improving the druggability of natural product: Why need drug delivery system?

P Tang, T Shen, H Wang, R Zhang, X Zhang… - Biomedicine & …, 2023 - Elsevier
Bioactive natural products (BNPs) are the marrow of medicinal plants, which are the
secondary metabolites of organisms and have been the most famous drug discovery …

[HTML][HTML] Ginsenoside Rk3 ameliorates Aβ-induced neurotoxicity in APP/PS1 model mice via AMPK signaling pathway

L She, L Xiong, L Li, J Zhang, J Sun, H Wu… - Biomedicine & …, 2023 - Elsevier
Alzheimer's disease (AD) has become a major public health problem affecting the elderly
population, and there is currently no effective treatment. Although the pathogenesis of AD is …

[HTML][HTML] Ginsenoside RK1 improves cognitive impairments and pathological changes in Alzheimer's disease via stimulation of the AMPK/Nrf2 signaling pathway

L She, J Sun, L Xiong, A Li, L Li, H Wu, J Ren, W Wang… - Phytomedicine, 2024 - Elsevier
Abstract Background The pathogenesis of Alzheimer's disease (AD) is complex, resulting in
unsatisfactory effects of single-target therapeutic drugs. Accumulation evidence suggests …

Rosmarinic acid in combination with ginsenoside Rg1 suppresses colon cancer metastasis via co-inhition of COX-2 and PD1/PD-L1 signaling axis

H Liu, R Deng, C Zhu, H Han, G Zong, L Ren… - Acta Pharmacologica …, 2024 - nature.com
Metastasis of colorectal cancer (CRC) is a leading cause of mortality among CRC patients.
Elevated COX-2 and PD-L1 expression in colon cancer tissue has been linked to distant …

Network pharmacology-based analysis of Jin-Si-Wei on the treatment of Alzheimer's disease

J Zhi, L Yin, Z Zhang, Y Lv, F Wu, Y Yang… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Jin-Si-Wei (JSW), a traditional Chinese medicine
(TCM) formula, have cognitive enhancing effect and delay the memory decline in an animal …

[HTML][HTML] Novel wine in an old bottle: Preventive and therapeutic potentials of andrographolide in atherosclerotic cardiovascular diseases

T Gou, M Hu, M Xu, Y Chen, R Chen, T Zhou… - Journal of …, 2023 - Elsevier
Atherosclerotic cardiovascular disease (ASCVD) frequently results in sudden death and
poses a serious threat to public health worldwide. The drugs approved for the prevention …

[HTML][HTML] Effect and mechanism of acupuncture on Alzheimer's disease: A review

L Wu, Y Dong, C Zhu, Y Chen - Frontiers in Aging Neuroscience, 2023 - frontiersin.org
With the development trend of an aging society, Alzheimer's disease (AD) has become an
urgent problem in the field of medicine worldwide. Cognitive impairment in AD patients …

[HTML][HTML] Targeting endothelial cells with golden spice curcumin: A promising therapy for cardiometabolic multimorbidity

F Tang, D Liu, L Zhang, LY Xu, JN Zhang… - Pharmacological …, 2023 - Elsevier
Cardiometabolic multimorbidity (CMM) is an increasingly significant global public health
concern. It encompasses the coexistence of multiple cardiometabolic diseases, including …

[HTML][HTML] Integrating network pharmacology, UPLC-Q–TOF–MS and molecular docking to investigate the effect and mechanism of Chuanxiong Renshen decoction …

ZJ Shen, YB Fu, JL Hou, LN Lin, XY Wang, CY Li… - Chinese Medicine, 2022 - Springer
Abstract Background and aim Chuanxiong Renshen decoction (CRD) is a traditional
Chinese medicine compound used to treat Alzheimer's disease (AD). However, the effects …