[HTML][HTML] Morphotype-specific effector functions of Cryptococcus neoformans PUM1

JN Kaur, JC Panepinto - Scientific Reports, 2016 - nature.com
The basidiomycete fungal pathogen Cryptococcus neoformans requires the PUF protein,
Pum1, for hyphal morphogenesis during sexual development. In this study we found that …

CNBP homologues Gis2 and Znf9 interact with a putative G-quadruplex-forming 3′ untranslated region, altering polysome association and stress tolerance in …

J Leipheimer, ALM Bloom, T Baumstark, JC Panepinto - Msphere, 2018 - Am Soc Microbiol
In Cryptococcus neoformans, mRNAs encoding ribosomal proteins (RP) are rapidly and
specifically repressed during cellular stress, and the bulk of this repression is mediated by …

[HTML][HTML] Tools for Assessing Translation in Cryptococcus neoformans

CM Knowles, KM McIntyre, JC Panepinto - Journal of Fungi, 2021 - mdpi.com
Cryptococcus neoformans is a ubiquitous environmental fungus capable of establishing an
infection in a human host. Rapid changes in environments and exposure to the host immune …

Contributions of Ccr4 and Gcn2 to the Translational Response of C. neoformans to Host-Relevant Stressors and Integrated Stress Response Induction

CM Knowles, D Goich, ALM Bloom, MC Kalem… - Mbio, 2023 - Am Soc Microbiol
In response to the host environment, the human pathogen Cryptococcus neoformans must
rapidly reprogram its translatome from one which promotes growth to one which is …

Distinct and redundant roles of exonucleases in Cryptococcus neoformans: Implications for virulence and mating

C Wollschlaeger, N Trevijano-Contador, X Wang… - Fungal Genetics and …, 2014 - Elsevier
Opportunistic pathogens like Cryptococcus neoformans are constantly exposed to changing
environments, in their natural habitat as well as when encountering a human host. This …

[PDF][PDF] S5.3a Unraveling the genetic determinants of virulence in Cryptococcus neoformans

K Jackson, D Kisakye, M Macchietto, P Tiffen… - Medical …, 2022 - academic.oup.com
S5. 3 Cellular pleomorphism and fungal virulence, September 22, 2022, 3: 00 PM-4: 30 PM
Cryptococcus neoformans is a human pathogenic basidiomycete yeast that can cause …

Arginine methylation of Puf4 drives diverse protein functions

MC Kalem, S Duffy, S Shen, JN Kaur, J Qu… - bioRxiv, 2022 - biorxiv.org
The evolutionarily conserved Pumilio domain-containing RNA binding proteins (RBPs) are
involved in many steps of post-transcriptional gene regulation, including RNA stability …

RNA biology and the adaptation of Cryptococcus neoformans to host temperature and stress

ALM Bloom, JC Panepinto - Wiley Interdisciplinary Reviews …, 2014 - Wiley Online Library
Cryptococcus neoformans is an environmental fungus that can cause severe disease in
humans. C. neoformans encounters a multitude of stresses within the human host to which it …

mRNA decay: an adaptation tool for the environmental fungal pathogen Cryptococcus neoformans

ALM Bloom, J Leipheimer… - Wiley Interdisciplinary …, 2017 - Wiley Online Library
Fungi are ubiquitous in the environment and humans constantly encounter them in the soil,
air, water, and food. The vast majority of these interactions are inconsequential. However, in …

Stress Responsive Translation Regulation in the Human Pathogen Cryptococcus neoformans

CM Knowles - 2023 - search.proquest.com
Cryptococcus neoformans is a ubiquitous environmental fungus and opportunistic human
pathogen, primarily impacting immunocompromised hosts such as those living with …