Cancer metastasis and therapy resistance are the major unsolved clinical challenges, and
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …

Stem cells have self-renewal capacities and the ability to give rise to differentiated cells
thereby sustaining tissues during homeostasis and injury. This structural hierarchy extends …

Epithelial-mesenchymal transition (EMT) is a transient, reversible process of cell de-
differentiation where cancer cells transit between various stages of an EMT continuum …

Background Exosome-mediated crosstalk between cancer cells and immune cells
contributes to tumor growth. In this study, we investigated the mechanism underlying the …

Epithelial-mesenchymal transition (EMT) enables cells to gain migratory and invasive
features underlined by major transcriptional and epigenetic reprogramming. However, most …

Canonical Wnt/β-catenin signaling is an established regulator of cellular state and its critical
contributions to tumor initiation, malignant tumor progression and metastasis formation have …

In this issue of Developmental Cell, Lüönd et al. developed a tracing system, using the
uncharacterized early epithelial-mesenchymal transition (EMT)-marker Tenascin C, to …

Metastasis is the leading driver of cancer-related death. Tumor cell plasticity associated with
the epithelial–mesenchymal transition (EMT), an embryonic program also observed in …

Thymic Stromal Lymphopoietin (TSLP) plays a prominent role in inducing type 2 immune
response, commonly associated with atopic diseases. TSLP-activated CD4+ T helper 2 cells …

The vast majority of breast cancer-associated deaths are due to metastatic spread of cancer
cells, a process aided by epithelial-to-mesenchymal transition (EMT). Mounting evidence …