[HTML][HTML] Targeting circular RNAs as a therapeutic approach: current strategies and challenges

AT He, J Liu, F Li, BB Yang - Signal transduction and targeted therapy, 2021 - nature.com
Significant progress has been made in circular RNA (circRNA) research in recent years.
Increasing evidence suggests that circRNAs play important roles in many cellular processes …

Endothelial to mesenchymal transition: role in physiology and in the pathogenesis of human diseases

S Piera-Velazquez, SA Jimenez - Physiological reviews, 2019 - journals.physiology.org
Numerous studies have demonstrated that endothelial cells are capable of undergoing
endothelial to mesenchymal transition (EndMT), a newly recognized type of cellular …

Circular RNA and its mechanisms in disease: from the bench to the clinic

B Han, J Chao, H Yao - Pharmacology & therapeutics, 2018 - Elsevier
The emerging recognition of the functional roles of circular RNAs (circRNAs) has given rise
to a new perspective regarding our understanding of cellular physiology and disease …

[HTML][HTML] The emerging roles and functions of circular RNAs and their generation

CY Yu, HC Kuo - Journal of biomedical science, 2019 - Springer
Circular RNAs (circRNAs) are closed long non-coding RNAs, in which the 5'and 3'termini
are covalently linked by back-splicing of exons from a single pre-mRNA. Emerging evidence …

Extracellular vesicle–mediated delivery of circular RNA SCMH1 promotes functional recovery in rodent and nonhuman primate ischemic stroke models

L Yang, B Han, Z Zhang, S Wang, Y Bai, Y Zhang… - Circulation, 2020 - Am Heart Assoc
Background: Stroke is a leading cause of adult disability that can severely compromise the
quality of life of patients, yet no effective medication currently exists to accelerate …

[HTML][HTML] Circular RNAs in Cancer: emerging functions in hallmarks, stemness, resistance and roles as potential biomarkers

M Su, Y Xiao, J Ma, Y Tang, B Tian, Y Zhang, X Li… - Molecular cancer, 2019 - Springer
Circular RNAs (circRNAs) are a class of RNA molecules with closed loops and high stability.
CircRNAs are abundantly expressed in eukaryotic organisms and exhibit both location-and …

An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations

U Dube, JL Del-Aguila, Z Li, JP Budde, S Jiang… - Nature …, 2019 - nature.com
Parietal cortex RNA-sequencing (RNA-seq) data were generated from individuals with and
without Alzheimer disease (AD; n control= 13; n AD= 83) from the Knight Alzheimer Disease …

Role of circular RNAs in brain development and CNS diseases

SL Mehta, RJ Dempsey, R Vemuganti - Progress in neurobiology, 2020 - Elsevier
In mammals, many classes of noncoding RNAs (ncRNAs) are expressed at a much higher
level in the brain than in other organs. Recent studies have identified a new class of ncRNAs …

[HTML][HTML] FTO-dependent m6A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke

B Li, W Xi, Y Bai, X Liu, Y Zhang, L Li, L Bian… - Nature …, 2023 - nature.com
Vascular repair is considered a key restorative measure to improve long-term outcomes after
ischemic stroke. N 6-methyladenosine (m6A), the most prevalent internal modification in …

[HTML][HTML] Circular RNA EIF4G3 suppresses gastric cancer progression through inhibition of β-catenin by promoting δ-catenin ubiquitin degradation and upregulating …

X Zang, J Jiang, J Gu, Y Chen, M Wang, Y Zhang… - Molecular Cancer, 2022 - Springer
Background Increasing studies suggest that circular RNAs (circRNAs) are critical regulators
of cancer development and progression. However, the biological roles and mechanisms of …