Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and CYP2C19 Genotypes and Dosing of Selective Serotonin Reuptake …

JK Hicks, JR Bishop, K Sangkuhl… - Clinical …, 2015 - Wiley Online Library
Selective serotonin reuptake inhibitors (SSRIs) are primary treatment options for major
depressive and anxiety disorders. CYP2D6 and CYP2C19 polymorphisms can influence the …

Review and consensus on pharmacogenomic testing in psychiatry

CA Bousman, SA Bengesser, KJ Aitchison… - …, 2021 - thieme-connect.com
The implementation of pharmacogenomic (PGx) testing in psychiatry remains modest, in part
due to divergent perceptions of the quality and completeness of the evidence base and …

Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting

LV Kalman, JAG Agúndez, ML Appell… - Clinical …, 2016 - Wiley Online Library
This article provides nomenclature recommendations developed by an international
workgroup to increase transparency and standardization of pharmacogenetic (PGx) result …

Effectiveness of pharmacogenomic tests including CYP2D6 and CYP2C19 genomic variants for guiding the treatment of depressive disorders: systematic review and …

D Arnone, O Omar, T Arora, L Östlundh… - Neuroscience & …, 2023 - Elsevier
Major depressive disorders are prevalent conditions with limited treatment response and
remission. Pharmacogenomics tests including CYP2D6 and CYP2C19 genomic variants …

[HTML][HTML] Pharmacogenomics: A road ahead for precision medicine in psychiatry

AF Pardiñas, MJ Owen, JTR Walters - Neuron, 2021 - cell.com
Psychiatric genomics is providing insights into the nature of psychiatric conditions that in
time should identify new drug targets and improve patient care. Less attention has been paid …

Constellation: a tool for rapid, automated phenotype assignment of a highly polymorphic pharmacogene, CYP2D6, from whole-genome sequences

GP Twist, A Gaedigk, NA Miller, EG Farrow… - NPJ genomic …, 2016 - nature.com
An important component of precision medicine—the use of whole-genome sequencing
(WGS) to guide lifelong healthcare—is electronic decision support to inform drug choice and …

Genetic variants in major depressive disorder: from pathophysiology to therapy

X Gonda, P Petschner, N Eszlari, D Baksa… - Pharmacology & …, 2019 - Elsevier
In spite of promising preclinical results there is a decreasing number of new registered
medications in major depression. The main reason behind this fact is the lack of confirmation …

Implementation of clinical pharmacogenomics within a large health system: from electronic health record decision support to consultation services

JK Hicks, D Stowe, MA Willner, M Wai… - … : The Journal of …, 2016 - Wiley Online Library
The number of clinically relevant gene‐based guidelines and recommendations pertaining
to drug prescribing continues to grow. Incorporating gene–drug interaction information into …

Pharmacogenetics of antipsychotics

EJ Brandl, JL Kennedy… - The Canadian Journal of …, 2014 - journals.sagepub.com
Objective: During the past decades, increasing efforts have been invested in studies to
unravel the influence of genetic factors on antipsychotic (AP) dosage, treatment response …

The role of genetics and genomics in clinical psychiatry

MR Hoehe, DJ Morris-Rosendahl - Dialogues in clinical …, 2018 - Taylor & Francis
The enormous successes in the genetics and genomics of many diseases have provided the
basis for the advancement of precision medicine. Thus, the detection of genetic variants …