Preservation of female genetics is currently done primarily by means of oocyte and embryo
cryopreservation. The field has seen much progress during its four-decade history, progress …

Oocyte maturation is a long process during which oocytes acquire their intrinsic ability to
support the subsequent stages of development in a stepwise manner, ultimately reaching …

The negative impact of obesity on reproductive success is well documented but the stages at
which development of the conceptus is compromised and the mechanisms responsible for …

In obesity, accumulation of lipid in nonadipose tissues, or lipotoxicity, is associated with
endoplasmic reticulum (ER) stress, mitochondrial dysfunction, and ultimately apoptosis. We …

Obesity is associated with infertility in women through multiple and complex mechanisms.
Briefly, the adipose tissue through the production of many factors, such as leptin, free fatty …

Lipids are a potential reservoir of energy for initial embryonic development before activation
of the embryonic genome and are involved in plasma membrane biosynthesis. Excessive …

BACKGROUND: Mitochondrial biogenesis and bioenergetics play an important role in
oocyte maturation and embryo development. We have investigated the relationship between …

Significance: The precipitous age-related decline in female fertility is intimately associated
with a reduction in both the quantity and quality of the germline (oocytes). Although complex …

STUDY QUESTION Are there age-related differences in gene expression during the
germinal vesicle (GV) to metaphase II (MII) stage transition in euploid human oocytes …

Glyphosate is a high-efficiency, low-toxicity, broad-spectrum herbicide. The residues of
glyphosate-based herbicides are frequent pollutants in the environment. However, the …