Targeting Nrf2 signaling pathway by quercetin in the prevention and treatment of neurological disorders: An overview and update on new developments

MY Zamanian, A Soltani, Z Khodarahmi… - Fundamental & …, 2023 - Wiley Online Library
Abstract Background: Neurological disorders (NLDs) are widely acknowledged as a
significant public health concern worldwide. Stroke, Alzheimer's disease (AD), and traumatic …

[HTML][HTML] Quercetin-conjugated superparamagnetic iron oxide nanoparticles protect AlCl3-induced neurotoxicity in a rat model of Alzheimer's disease via antioxidant …

E Amanzadeh Jajin, A Esmaeili, S Rahgozar… - Frontiers in …, 2021 - frontiersin.org
Alzheimer's disease (AD) is a neurodegenerative disease with cognitive impairment.
Oxidative stress in neurons is considered as a reason for development of AD. Antioxidant …

[HTML][HTML] A meta-analysis of Alzheimer's disease's relationship with human ApoE gene variants

X Xu, B Zhang, X Wang, Q Zhang, X Wu… - American Journal of …, 2021 - ncbi.nlm.nih.gov
Purpose: To explore the association between Alzheimer's disease and apolipoprotein E
(ApoE). Studies on this relationship are plentiful, but they mostly suffer from the …

Treatment of Alzheimer's disease by natural products

S Chougle, D Kumar, A Khan, S Zehra… - Journal of Experimental …, 2021 - dergipark.org.tr
Alzheimer's disease is a neurological disorder that progressively affects the brain cells. It is
sometimes accompanied with dementia and commonly seen in elderly people. It ultimately …

[HTML][HTML] Advanced patient-specific microglia cell models for pre-clinical studies in Alzheimer's disease

C Cuní-López, R Stewart… - Journal of …, 2024 - jneuroinflammation.biomedcentral …
Alzheimer's disease (AD) is an incurable neurodegenerative disorder with a rapidly
increasing prevalence worldwide. Current approaches targeting hallmark pathological …

Association of CHAT Gene Polymorphism rs3793790 and rs2177370 with Donepezil Response and the Risk of Alzheimer's Disease Continuum

H Sun, C Lv, X Zhang, X Sun, S Chen, K Li… - … Interventions in Aging, 2024 - Taylor & Francis
Background Genetic variation plays an important role in drug response, there are few
relevant studies on patients with Alzheimer's disease continuum (ADC). Objective This study …

Exploring Antioxidant and α-Glucosidase Inhibitory Activities in Mulberry Leaves (Morus alba L.) across Growth Stages: A Comprehensive Metabolomic Analysis with …

W Li, S Hao, H Li, Q An, L Yang, B Guo, Z Xue, Y Liu… - Molecules, 2023 - mdpi.com
Metabolic product accumulation exhibited variations among mulberry (Morus alba L.) leaves
(MLs) at distinct growth stages, and this assessment was conducted using a combination of …

Brain Age Is Associated with Cognitive Outcomes of Cholinesterase Inhibitor Treatment in Patients with Mild Cognitive Impairment

WYI Tseng, YC Hsu, LK Huang… - Journal of …, 2024 - content.iospress.com
Background: The effect of cholinesterase inhibitor (ChEI) on mild cognitive impairment (MCI)
is controversial. Brain age has been shown to predict Alzheimer's disease conversion from …

Use of online sequential segmented heart cutting modulation and orthogonality approach for determination of isomeric impurity profile of a drug molecule using …

RC Prabhu, A Maruthapillai, GC Senadi… - Microchemical Journal, 2023 - Elsevier
Determination of impurity profile including chiral and achiral impurities is challenging as well
as time consuming while analysis of the active moiety. With the recent evolution of 2 …

Genetic editing and pharmacogenetics in current and future therapy of neurocognitive disorders

M Prendecki, M Kowalska, E Toton… - Current Alzheimer …, 2020 - ingentaconnect.com
Dementia is an important issue in western societies, and in the following years, this problem
will also rise in the developing regions, such as Africa and Asia. The most common types of …