The pancreas is an essential organ for proper nutrient metabolism and has both endocrine
and exocrine function. In the past two decades, knowledge of how the pancreas develops …

The pancreas is an endoderm-derived glandular organ that participates in the regulation of
systemic glucose metabolism and food digestion through the function of its endocrine and …

Vascular endothelial growth factor-A (VEGF-A) has long been recognized as the key
regulator of vascular development and function in health and disease. VEGF is a secreted …

The progressive loss of pancreatic β‐cell mass that occurs in both type 1 and type 2
diabetes is a primary factor driving efforts to identify strategies for effectively increasing …

Pancreatic islet endocrine cell and endothelial cell (EC) interactions mediated by vascular
endothelial growth factor-A (VEGF-A) signaling are important for islet differentiation and the …

The pancreas is an essential endoderm-derived organ that ensures nutrient metabolism via
its endocrine and exocrine functions. Here we review the essential processes governing the …

The vasculature of an organism has the daunting task of connecting all the organ systems to
nourish tissue and sustain life. This complex network of vessels and associated cells must …

Many embryonic organs undergo branching morphogenesis to maximize their functional
epithelial surface area. Branching morphogenesis requires the coordinated interplay of …

Human and rodent islets differ substantially in several features, including architecture, cell
composition, gene expression and some aspects of insulin secretion. Mouse pancreatic …

Objectives The aim of this study was to provide a comprehensive overview of the clinically
relevant anatomical and histological aspects of the development of the human pancreas …