The relentless nature and increasing prevalence of human pancreatic diseases, in
particular, diabetes mellitus and adenocarcinoma, has motivated further understanding of …

Chronic kidney disease (CKD) and end stage renal disease (ESRD) are increasingly
frequent and devastating conditions that have driven a surge in the need for kidney …

Vascular biology is an important scientific domain that has gradually penetrated many
medical and scientific fields. Scientists are most often focused on present problems in their …

Blood vessels course through organs, providing them with essential nutrient and gaseous
exchange. However, the vasculature has also been shown to provide non-nutritional signals …

Pancreatic islets are highly vascularized mini-organs, and vascular endothelial growth factor
(VEGF)-A is a critical factor in the development of islet vascularization. To investigate the …

Recently, blood vessels have been implicated in the morphogenesis of various organs. The
vasculature is also known to be essential for endochondral bone development, yet the …

In the mammalian pancreas, endocrine cells undergo lineage allocation upon emergence
from a bipotent duct/endocrine progenitor pool, which resides in the “trunk epithelium.” Major …

The kidney vasculature facilitates the excretion of wastes, the dissemination of hormones,
and the regulation of blood chemistry. To carry out these diverse functions, the vasculature is …

At the time the first pancreas transplant was performed by Kelly and Lillehei in 1966, insulin
therapy for diabetes was generally available but administered in a form that is known today …

This review summarizes our current understanding of exocrine pancreas development,
including the formation of acinar, ductal and centroacinar cells. We discuss the transcription …