Heat stroke is a life-threatening illness that affects all segments of society, including the
young, aged, sick, and healthy. The recent high death toll in France (Dorozynski, 2003) and …

The ability to make genetic changes in the mouse germline in a predetermined way has
resulted from the combination of two technologies developed during the past 10 years. The …

The acid-sensing ion channel 1a (ASIC1a) is abundantly expressed in the amygdala
complex and other brain regions associated with fear. Studies of mice with a disrupted …

Transgenic mice were generated containing a 1542-base pair fragment of the kidney
androgen-regulated protein (KAP) promoter fused to the human angiotensinogen (HAGT) …

A revolution in molecular biological technology has allowed, for the first time, the study of
pain at the level of the gene. The molecular genetic technique currently garnering the most …

The brain renin-angiotensin system (RAS) has long been considered pivotal in
cardiovascular regulation and important in the pathogenesis of hypertension and heart …

To examine the physiological importance of brain angiotensin II type 1 (AT1) receptors, we
developed a novel transgenic mouse model with rat AT1a receptors targeted selectively to …

In vertebrates, three troponin T (TnT) genes, cardiac TnT (cTnT), skeletal muscle fast‐twitch
TnT (fTnT), and slow‐twitch TnT (sTnT), have evolved for the regulation of striated muscle …

The thermoregulatory changes induced by prolonged heat exposure consist of hyperthermia
in response to direct heat exposure, and a biphasic response consisting of hypothermia …

Abstract Soluble colony-stimulating factor-1 (sCSF-1) and membrane bound CSF-1 are
synthesized by osteoblasts and stromal cells. However, the precise role of each form in …