[HTML][HTML] The major subunit of the asialoglycoprotein receptor is expressed on the hepatocellular surface in mice lacking the minor receptor subunit
JR Braun, TE Willnow, S Ishibashi, G Ashwell… - Journal of Biological …, 1996 - ASBMB
The mammalian asialoglycoprotein receptor (ASGPR) is located on the sinusoidal
membrane of hepatocytes where it binds and endocytoses galactose-terminated …
membrane of hepatocytes where it binds and endocytoses galactose-terminated …
Targeted gene delivery into HepG2 cells using complexes containing DNA, cationized asialoorosomucoid and activated cationic liposomes
Unilamellar activated cationic liposomes containing 3β [N-(N′, N′-dimethylaminopropane
)-carbamoyl] cholesterol, dioleoyl phosphatidylethanolamine (DOPE) and the N …
)-carbamoyl] cholesterol, dioleoyl phosphatidylethanolamine (DOPE) and the N …
Binding assay between murine Dectin-1 and β-glucan/DNA complex with quartz-crystal microbalance
S Mochizuki, H Morishita, Y Adachi, Y Yamaguchi… - Carbohydrate …, 2014 - Elsevier
A β-glucan called schizophyllan (SPG) forms a stoichiometric complex with polynucleotides
with its two main chain glucoses interacting with one nucleotide base. This complex can be …
with its two main chain glucoses interacting with one nucleotide base. This complex can be …
[HTML][HTML] Ligand-induced endocytosis of the asialoglycoprotein receptor: evidence for heterogeneity in subunit oligomerization
MD Bider, M Spiess - FEBS letters, 1998 - Elsevier
The hepatic asialoglycoprotein receptor, a non-covalent hetero-oligomer of two subunits, is
a constitutively cycling endocytic receptor. However, the ligand asialoorosomucoid caused …
a constitutively cycling endocytic receptor. However, the ligand asialoorosomucoid caused …
Isolated rat hepatocytes bind lactoferrins by the RHL-1 subunit of the asialoglycoprotein receptor in a galactose-independent manner
DJ Bennatt, YY Ling, DD McAbee - Biochemistry, 1997 - ACS Publications
Isolated rat hepatocytes bind and internalize the iron-binding protein lactoferrin (Lf) by a set
of high-affinity, recycling, Ca2+-dependent binding sites. We have purified a 45-kDa …
of high-affinity, recycling, Ca2+-dependent binding sites. We have purified a 45-kDa …
[HTML][HTML] A new splice variant of the major subunit of human asialoglycoprotein receptor encodes a secreted form in hepatocytes
J Liu, B Hu, Y Yang, Z Ma, Y Yu, S Liu, B Wang… - PLoS …, 2010 - journals.plos.org
Background The human asialoglycoprotein receptor (ASGPR) is composed of two
polypeptides, designated H1 and H2. While variants of H2 have been known for decades …
polypeptides, designated H1 and H2. While variants of H2 have been known for decades …
Intrinsic factor, haptocorrin, and their receptors
DH Alpers, GJ Russell-Jones - Chemistry and Biochemistry of B, 1999 - books.google.com
3.1 Occurrence and Distribution 3.2 Development and Differentiation 3.3 Structure and
Function 3.4 Synthesis and Secretion 3.5 Cellular Uptake and Utilization of IF-Cbl 4 …
Function 3.4 Synthesis and Secretion 3.5 Cellular Uptake and Utilization of IF-Cbl 4 …
A novel hepatic-targeting system for therapeutic cytokines that delivers to the hepatic asialoglycoprotein receptor, but avoids receptor-mediated endocytosis
H Sato, Y Kato, E Hayashi, T Tabata, M Suzuki… - Pharmaceutical …, 2002 - Springer
Purpose. To demonstrate the utilities of a synthetic low-affinity ligand ((Gal) 3) for the
asialoglycoprotein receptor (ASGP-R) as a hepatic targeting device for therapeutic …
asialoglycoprotein receptor (ASGP-R) as a hepatic targeting device for therapeutic …
Novel neo glycolipid: formulation into PEGylated cationic liposomes and targeting of DNA lipoplexes to the hepatocyte-derived cell line HepG2
Liver parenchymal cells are an important target for the treatment of several metabolic and
viral disorders. Corrective gene delivery for this purpose is an avenue that is receiving …
viral disorders. Corrective gene delivery for this purpose is an avenue that is receiving …
Functional evaluation of poly-(N-ρ-vinylbenzyl-O-β-Dgalactopyranosyl-[1-4]-D-gluconamide)(PVLA) as a liver specific carrier
Y Watanabe, X Liu, I Shibuya… - Journal of Biomaterials …, 2000 - Taylor & Francis
Hepatocytes express the specific C-type lectin, asialoglycoprotein (ASGP) receptor, on the
surface to remove the ligand-bearing proteins from circulation. The specific expression and …
surface to remove the ligand-bearing proteins from circulation. The specific expression and …