The lens is a multicellular, but avascular tissue that must stay transparent to allow normal
transmission of light and focusing of it on the retina. Damage to lens cells and/or proteins …

The lens is an avascular organ composed of an anterior epithelial cell layer and fiber cells
that form the bulk of the organ. The lens expresses connexin43 (Cx43), connexin46 (Cx46) …

Gap junction channels facilitate the intercellular exchange of ions and small molecules, a
process that is critical for the function of many different kinds of cells and tissues. Recent …

A gap junction (GJ) channel is formed by docking of two GJ hemichannels and each of these
hemichannels is a hexamer of connexins. All connexin genes have been identified in …

Connexin channels mediate electrical coupling, intercellular molecular signaling, and
extracellular release of signaling molecules. Connexin proteins assemble intracellularly as …

The mutation N188T in human connexin46 (hCx46) correlates with a congenital nuclear
pulverulent cataract. This mutation is in the second extracellular loop, a domain involved in …

Mutations in connexin 46 are associated with congenital cataracts. The purpose of this
project was to characterize cellular and functional properties of two congenital cataract …

The present study aimed to explore the feasibility of using antisense connexin (Cx) treatment
to promote corneal wound healing, and to investigate the changes of Cx gap junction …

Background Germ cell tumors are relatively common in young men. They derive from a non-
invasive precursor, called germ cell neoplasia in situ, but the exact pathogenesis is still …

Autosomal dominant congenital cataract (ADCC) is a clinically and genetically
heterogeneous ocular disease in children that results in serious visual impairments or even …