Interleukin-23 (IL-23) is a pro-inflammatory cytokine composed of two subunits, IL-23A (p19)
and IL-12/23B (p40), the latter shared with Interleukin-12 (IL-12). IL-23 is mainly produced …

Abstract Interleukin-6 (IL-6) is a pivotal cytokine with a diverse repertoire of physiological
functions that include regulation of immune cell proliferation and differentiation …

The function of interleukin-22 (IL-22) in intestinal barrier homeostasis remains controversial.
Here, we map the transcriptional landscape regulated by IL-22 in human colonic epithelial …

Upon antigenic stimulation, naïve CD4+ T cells differentiate into different subsets and
secrete various cytokines to exert biological effects. Th22 cells, a newly identified CD4+ T …

Cytokines provide cells with the ability to communicate with one another and orchestrate
complex multicellular behaviour. There is an emerging understanding of the role that …

Environmental genotoxic factors pose a challenge to the genomic integrity of epithelial cells
at barrier surfaces that separate host organisms from the environment. They can induce …

Increased understanding of the biology of interleukin 17 (IL-17) has revealed that this
cytokine is a central player in immunity at the sites most exposed to microorganisms …

Abstract CD4+ T helper (Th) cells are critical for proper immune cell homeostasis and host
defense, but are also major contributors to pathology of autoimmune and inflammatory …

INTRODUCTION The combination of food intake and the resident gut microbiota exposes
the gastrointestinal (GI) tract to numerous antigens. Intestinal epithelial cells (ECs) compose …

A critical role for IL-17, a cytokine produced by T helper 17 (Th17) cells, has been indicated
in the pathogenesis of chronic inflammatory and autoimmune diseases. A positive effect of …