Sleep is critical for diverse aspects of brain function in animals ranging from invertebrates to
humans. Powerful genetic tools in the fruit fly Drosophila melanogaster have identified—at …

This review focuses on neuropeptides and peptide hormones, the largest and most diverse
class of neuroactive substances, known in Drosophila and other animals to play roles in …

Animals discriminate stimuli, learn their predictive value and use this knowledge to modify
their behavior. In Drosophila, the mushroom body (MB) plays a key role in these processes …

During sleep, animals do not eat, reproduce or forage. Sleeping animals are vulnerable to
predation. Yet, the persistence of sleep despite evolutionary pressures, and the deleterious …

Sleep is under homeostatic control, whereby increasing wakefulness generates sleep need
and triggers sleep drive. However, the molecular and cellular pathways by which sleep need …

Neuropeptides are by far the largest and most diverse group of signaling molecules in
multicellular organisms. They are ancient molecules important in regulating a multitude of …

Plasticity in animal behaviour relies on the ability to integrate external and internal cues from
the changing environment and hence modulate activity in synaptic circuits of the brain. This …

Sleep promotes memory consolidation in humans and many other species, but the
physiological and anatomical relationships between sleep and memory remain unclear …

Although glucose-sensing neurons were identified more than 50 years ago, the
physiological role of glucose sensing in metazoans remains unclear. Here we identify a pair …

Feeding and sleep are fundamental behaviours with significant interconnections and cross-
modulations. The circadian system and peptidergic signals are important components of this …