Acridine derivatives are interesting chemotherapeutic agents that were first used as
antibacterial and antiparasite agents. In this review we wish to concentrate our attention on …

Abstract Alzheimer's disease (AD), the most common progressive neurodegenerative
disorder, is characterized by severe cognitive decline and personality changes as a result of …

Following trauma or ischemia to the central nervous system (CNS), there is a marked
increase in the expression of cell cycle-related proteins. This up-regulation is associated …

To evaluate the contribution of NF-κB and the NF-κB target gene p53 to nigral dopaminergic
neuron degeneration in rodent models of Parkinson's disease, time-course of dopaminergic …

Oxidative DNA damage induces changes in the neuronal cell cycle and activates a DNA
damage response (DDR) to promote repair, but these processes may be altered under a …

Aging encompasses life itself so understanding requires frameworks that forge unity amidst
complexity. The free radical theory of aging is one example. The original focus on damage …

Reactive oxygen species and oxidative stress are associated with neuronal cell death in
many neurodegenerative conditions. However, the exact molecular mechanisms triggered …

Although the concepts of secondary injury and neuroprotection after neurotrauma are
experimentally well supported, clinical trials of neuroprotective agents in traumatic brain …

Neurodegenerative diseases as Alzheimer's disease, Parkinson's disease and other
neurological disorders remain major problem worldwide since is currently no effective …

Background Identification of functional non-coding variants and their mechanistic
interpretation is a major challenge of modern genomics, especially for precision medicine …