Caspase-recruitment domain 9 (CARD9) protein is expressed in many cells especially in
immune cells, and is critically involved in the function of the innate and adaptive immune …

At least 20% of B cells in the periphery expresses an antigen receptor with a degree of self‐
reactivity. If activated, these autoreactive B cells pose a risk as they can contribute to the …

Abstract Tyrosine-protein kinase Lyn (LynK) has emerged as one of the most attractive
therapeutic targets for cancer and diabetes. In this study, we used a multistep virtual …

Summary LRH-1/NR5A2 is implicated in islet morphogenesis postnatally, and its activation
using the agonist BL001 protects islets against apoptosis, reverting hyperglycemia in mouse …

Stimulation of the innate immune system is crucial in both effective vaccinations and
immunotherapies. This is often achieved through adjuvants, molecules that usually activate …

Highlights•Myeloid-cell regulation optimizes innate/adaptive immunity and tissue
health.•Competing positive and negative signaling biases and tunes myeloid activation.•Src …

C-terminal Src kinase (CSK) is a cytosolic tyrosine-protein kinase with an important role in
regulating critical cellular decisions, such as cellular apoptosis, survival, proliferation …

Introduction Cancer is a crucial public health problem and one of the leading causes of
death worldwide. Previous studies have suggested that GPX3 may be involved in cancer …

Background: The pathogenesis and diagnosis of Ankylosing Spondylitis (AS) has remained
uncertain due to several reasons, including the lack of studies on the local and systemic …

Abstract Background and Objectives Parkinson's disease (PD) and chronic periodontitis
(CP) are both inflammatory diseases; a correlation between the two diseases has been …