Neurological and immunological signals constitute an extensive regulatory network in our
body that maintains physiology and homeostasis. The cholinergic system plays a significant …

Tobacco and nicotine use are associated with disease susceptibility and progression.
Health challenges associated with nicotine and smoking include developmental delays …

The nicotinic acetylcholine receptor has served, since its biochemical identification in the
1970s, as a model of an allosteric ligand-gated ion channel mediating signal transition at the …

The α 7-type nicotinic acetylcholine receptor is one of the most unique and interesting of all
the members of the cys-loop superfamily of ligand-gated ion channels. Since it was first …

SARS-CoV-2 is a new coronavirus that has caused a worldwide pandemic. It causes severe
acute respiratory syndrome (COVID-19), which is fatal in many cases, and is characterized …

BACKGROUND One hundred years ago, experiments on beating frog hearts identified
acetylcholine (ACh) as the seminal neurotransmitter. Sixty years later, fractionation of the eel …

Cholinergic innervation of the hippocampus uses the neurotransmitter acetylcholine (ACh)
to coordinate neuronal circuit activity while simultaneously influencing the function of non …

Nicotinic acetylcholine receptors are not only expressed by the nervous system and at the
neuro-muscular junction but also by mononuclear phagocytes, which belong to the innate …

There is an urgent need to address the devastating pandemic, COVID‐19, caused by SARS‐
CoV‐2. The efforts to understand the details of this disease in hope of providing effective …

The α7 nicotinic acetylcholine receptor is a pentameric ligand-gated ion channel that plays
an important role in cholinergic signaling throughout the nervous system. Its unique …