The sarco (endo) plasmic reticulum calcium ATPase (SERCA) is responsible for transporting
calcium (Ca2+) from the cytosol into the lumen of the sarcoplasmic reticulum (SR) following …

Akt is a central player in the signal transduction pathways activated in response to many
growth factors, hormones, cytokines, and nutrients and is thought to control a myriad of …

Heart failure (HF) imposes significant economic and public health burdens upon modern
society. It is known that disturbances in neurohormonal status play an important role in the …

The management of patients with shock is extremely challenging because of the myriad of
possible clinical presentations in cardiogenic shock, septic shock and hypovolemic shock …

The cardiac extracellular matrix (ECM) provides the architectural scaffold to support efficient
contraction and relaxation of cardiomyocytes. The elegant design of the ECM facilitates …

Regeneration of chronic myocardial infarction (CMI) is one of the challenging issues due to
its limited regeneration activity compared to acute or sub-acute stage. In this study, we …

Aims Reactive pulmonary hypertension (PH) is a severe form of PH secondary to left‐sided
heart failure (HF). Given the structural and functional abnormalities in the pulmonary …

Background Acute kidney injury (AKI) is a syndrome characterized by the rapid loss of the
kidney excretory function and is strongly associated with increased early and long-term …

Acute respiratory distress syndrome (ARDS) is a major concern in critical care medicine with
a high mortality of over 30%. Injury to the lungs is caused not only by underlying …

Thermolysin is a bacterial proteolytic enzyme, considered by many authors as a
pharmacological and biological model of other mammalian enzymes, with similar structural …