Bridging smart nanosystems with clinically relevant models and advanced imaging for precision drug delivery

Q Zhou, Q Liu, Y Wang, J Chen, O Schmid… - Advanced …, 2024 - Wiley Online Library
Intracellular delivery of nano‐drug‐carriers (NDC) to specific cells, diseased regions, or
solid tumors has entered the era of precision medicine that requires systematic knowledge …

Modeling the neuroimmune system in Alzheimer's and Parkinson's diseases

W Balestri, R Sharma, VA da Silva, BC Bobotis… - Journal of …, 2024 - Springer
Parkinson's disease (PD) and Alzheimer's disease (AD) are neurodegenerative disorders
caused by the interaction of genetic, environmental, and familial factors. These diseases …

Meta-analysis of the make-up and properties of in vitro models of the healthy and diseased blood–brain barrier

JG Shamul, Z Wang, H Gong, W Ou, AM White… - Nature Biomedical …, 2024 - nature.com
In vitro models of the human blood–brain barrier (BBB) are increasingly used to develop
therapeutics that can cross the BBB for treating diseases of the central nervous system. Here …

Advances in the knowledge and therapeutics of schizophrenia, major depression disorder, and bipolar disorder from human brain organoid research

R Villanueva - Frontiers in Psychiatry, 2023 - frontiersin.org
Tridimensional cultures of human induced pluripotent cells (iPSCs) experimentally directed
to neural differentiation, termed “brain organoids” are now employed as an in vitro assay that …

On-chip physiological mimicry of neurovascular unit: challenges and perspectives

SI Ahn, YT Kim - Neural Regeneration Research, 2024 - journals.lww.com
Neurological disorders including neurodegenerative diseases, brain tumors, and stroke are
the second leading cause of death and the greatest cause of disability worldwide. However …

Reconstitution of human tissue barrier function for precision and personalized medicine

J Kim, T Yoon, S Lee, PJ Kim, YT Kim - Lab on a Chip, 2024 - pubs.rsc.org
Tissue barriers in a body, well known as tissue-to-tissue interfaces represented by
endothelium of the blood vessels or epithelium of organs, are essential for maintaining …

Engineering brain-on-a-chip platforms

B Servais, N Mahmoudi, V Gautam, W Tong… - Nature Reviews …, 2024 - nature.com
The increasing prevalence of neurological and psychiatric diseases, such as Alzheimer
disease and schizophrenia, necessitates the development of new research tools to …

[HTML][HTML] Advances and Challenges of Bioassembly Strategies in Neurovascular In Vitro Modeling: An Overview of Current Technologies with a Focus on Three …

S Mancuso, A Bhalerao… - International Journal of …, 2024 - pmc.ncbi.nlm.nih.gov
Bioassembly encompasses various techniques such as bioprinting, microfluidics, organoids,
and self-assembly, enabling advances in tissue engineering and regenerative medicine …

神经血管单元的片上生理模拟: 挑战与展望

SI Ahn, YT Kim - 中国神经再生研究(英文版), 2024 - sjzsyj.com.cn
Neurological disorders including neurodegenerative diseases, brain tumors, and stroke are
the second leading cause of death and the greatest cause of disability worldwide. However …