The roles of macrophages and microglia in multiple sclerosis and experimental autoimmune encephalomyelitis

F Chu, M Shi, C Zheng, D Shen, J Zhu, X Zheng… - Journal of …, 2018 - Elsevier
Multiple sclerosis (MS) is an autoimmune and neurodegenerative disorder characterized by
chronic inflammation, demyelination, as well as axonal and neuronal loss in the central …

Innate, innate-like and adaptive lymphocytes in the pathogenesis of MS and EAE

L Van Kaer, JL Postoak, C Wang, G Yang… - Cellular & molecular …, 2019 - nature.com
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS) in which the immune system damages the protective insulation surrounding the nerve …

Gut microbiota in multiple sclerosis and experimental autoimmune encephalomyelitis: current applications and future perspectives

F Chu, M Shi, Y Lang, D Shen, T Jin… - Mediators of …, 2018 - Wiley Online Library
The gut environment and gut microbiome dysbiosis have been demonstrated to significantly
influence a range of disorders in humans, including obesity, diabetes, rheumatoid arthritis …

Microglial priming of antigen presentation and adaptive stimulation in Alzheimer's disease

R Das, S Chinnathambi - Cellular and Molecular Life Sciences, 2019 - Springer
The prominent pathological consequences of Alzheimer's disease (AD) are the misfolding
and mis-sorting of two cellular proteins, amyloid-β and microtubule-associated protein Tau …

NLR-dependent regulation of inflammation in multiple sclerosis

M Gharagozloo, KV Gris, T Mahvelati… - Frontiers in …, 2018 - frontiersin.org
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS)
associated with inappropriate activation of lymphocytes, hyperinflammatory responses …

Exploring the Gut-Brain Axis for the Control of CNS Inflammatory Demyelination: Immunomodulation by Bacteroides fragilis' Polysaccharide A

D Erturk-Hasdemir, J Ochoa-Repáraz… - Frontiers in …, 2021 - frontiersin.org
The symbiotic relationship between animals and their resident microorganisms has
profound effects on host immunity. The human microbiota comprises bacteria that reside in …

The regulatory role of NLRX1 in innate immunity and human disease

M Liu, K Liu, D Cheng, B Zheng, S Li, Z Mo - Cytokine, 2022 - Elsevier
Nucleotide binding and oligomerization domain (NOD)-like receptor (NLR) initially appeared
in the public view as a cytoplasmic pathogen recognition receptor (PRR) that plays an …

The role of distinct subsets of macrophages in the pathogenesis of MS and the impact of different therapeutic agents on these populations

M Radandish, P Khalilian, N Esmaeil - Frontiers in Immunology, 2021 - frontiersin.org
Multiple sclerosis (MS) is a demyelinating inflammatory disorder of the central nervous
system (CNS). Besides the vital role of T cells, other immune cells, including B cells, innate …

The Helminth Parasite Heligmosomoides polygyrus Attenuates EAE in an IL-4Rα-Dependent Manner

MPJ White, CJC Johnston, JR Grainger… - Frontiers in …, 2020 - frontiersin.org
Helminth parasites are effective in biasing Th2 immunity and inducing regulatory pathways
that minimize excessive inflammation within their hosts, thus allowing chronic infection to …

Beneficial roles of microglia and growth factors in MS, a brief review

V Pons, S Rivest - Frontiers in Cellular Neuroscience, 2020 - frontiersin.org
Microglia are the brain resident immune cells; they can produce a large variety of growth
factors (GFs) to prevent neuronal damages and promote recovery. In neurodegenerative …