Calcium (Ca2+) is a unique mineral that serves as both a nutrient and a signal in all
eukaryotes. To maintain Ca2+ homeostasis for both nutrition and signaling purposes, the …

Diabetic peripheral neuropathy (DPN) is the most common complication of diabetes, with
several underlying pathophysiological mechanisms, some of which are still uncertain. The …

Three-dimensional hydrogel-based organ-like cultures can be applied to study
development, regeneration, and disease in vitro. However, the control of engineered …

Mitochondria are structurally and functionally distinct organelles that produce adenosine
triphosphate (ATP) through oxidative phosphorylation (OXPHOS), to provide energy to …

The field of epitranscriptomics examines the recently deciphered form of gene expression
regulation that is mediated by type-and site-specific RNA modifications. Similarly to the role …

The function of neuronal circuits relies on the properties of individual neuronal cells and
their synapses. We propose that a substantial degree of synapse formation and function is …

Skeletal tissue is highly innervated. Although different types of nerves have been recently
identified in the bone, the crosstalk between bone and nerves remains unclear. In this …

Although cell transplantation can rescue motor defects in Parkinson's disease (PD) models,
whether and how grafts functionally repair damaged neural circuitry in the adult brain is not …

Elucidating the regulatory mechanisms of human brain evolution is essential to
understanding human cognition and mental disorders. We generated multi-omics profiles …

During development of the central nervous system (CNS), neurons polarize and rapidly
extend their axons to assemble neuronal circuits. The growth cone leads the axon to its …