During development of the central nervous system (CNS), neurons polarize and rapidly
extend their axons to assemble neuronal circuits. The growth cone leads the axon to its …

The spinal cord receives, relays and processes sensory information from the periphery and
integrates this information with descending inputs from supraspinal centres to elicit precise …

Osteocytes are master regulators of the skeleton. We mapped the transcriptome of
osteocytes from different skeletal sites, across age and sexes in mice to reveal genes and …

Cofilin is best known for its ability to sever actin filaments and facilitate cytoskeletal recycling
inside of cells, but at higher concentrations in vitro, cofilin stabilizes a more flexible, hyper …

Neurite outgrowth underlies the wiring of the nervous system during development and
regeneration. Despite a significant body of research, the underlying cytoskeletal mechanics …

As the nervous system develops, newly differentiated neurons need to extend their axons
toward their synaptic targets to form functional neural circuits. During this highly dynamic …

Coupling during bone remodeling refers to the spatial and temporal coordination of bone
resorption with bone formation. Studies have assessed the subtle interactions between …

Innervation plays a pivotal role as a driver of tissue and organ development as well as a
means for their functional control and modulation. Therefore, innervation should be carefully …

Axonal growth cones mediate axonal guidance and growth regulation. We show that
migrating neurons in mice possess a growth cone at the tip of their leading process, similar …

Local translation is rapidly regulated by extrinsic signals during neural wiring, but its control
mechanisms remain elusive. Here we show that the extracellular cue Sema3A induces an …