Despite the formidable mutational capacity and sequence diversity of HIV-1, evidence
suggests that viral evolution in response to specific selective pressures follows generally …

Host factors play an important role in determining rates of disease progression in human
immunodeficiency virus (HIV)‐infected individuals. HIV is able lo subvert the host immune …

Background & Aims: High rate of chronicity after acute hepatitis C virus (HCV) infection
cannot be explained in the presence of a multispecific cytotoxic T lymphocyte (CTL) …

Despite a strong cytotoxic T‐lymphocyte (CTL) response directed against viral antigens,
untreated individuals infected with the human immunodeficiency virus (HIV‐1) develop …

Publisher Summary This chapter discusses the potential role of CD8+ lymphocytes in the
immunopathogenesis of HIV-1 infection. The chapter describes both the cytolytic and …

Effective preventive and therapeutic intervention in individuals exposed to or infected with
human immunodeficiency virus (HIV) depends, in part, on a clear understanding of the …

Hepatitis C virus (HCV) is yet another example of a pathogen that persists in the presence of
a readily apparent immune response. As evidence for both humoral and cellular immune …

We examine simple mathematical models to investigate the circumstances under which the
dynamics of cytotoxic T–lymphocyte (CTL) activation and differentiation may result in the …

We analyse mathematical models comparing thein vivodynamics of macrophage-and T cell
infection by HIV. Experiments suggest that HIV can only replicate in activated T cells …

The ability of an AIDS virus to escape from immune containment by selective mutation away
from recognition by CTL was explored in simian immunodeficiency virus of macaques …