Abstract CD8+ cytotoxic T lymphocytes (CTL) play an important role in HIV-1 infection.
However, in most persons the HIV-1-specific CTL become dysfunctional. It has been …

Cytotoxic T lymphocytes (CTLs) are considered to play an important role in the containment
of HIV-1 infection. Their efficacy is, however, limited as they also continuously select for HIV …

Mathematical models, which are based on a firm understanding of biological interactions,
can provide nonintuitive insights into the dynamics of host responses to infectious agents …

Cytotoxic T cells are believed to be an important immune response in HIV infection, both in
the initial response to viraemia, and in controlling HIV replication and maintaining clinical …

Abstract When the National Institutes of Health (NIH) decided in 1994 that there was
insufficient scientific evidence to justify progression of human immunodeficiency virus (HIV) …

Human immunodeficiency virus type-1 (HIV-1) affects more than 30 million people
worldwide and has accounted for over 30 million deaths. The advent of combination …

Human immunodeficiency virus (HIV) has one of the highest incidence and mortality rates of
any infectious disease, with more than 33 million people infected worldwide. Specifically …

Polymorphism in the Human Leucocyte Antigen (HLA) region of chromosome is the major
source of host genetic variability in outcome of HIV-1 infection. However, there is limited …

1. ABSTRACT [Objective] HLA class I (HLA-I) restricted CTL responses drive HIV evolution
through selection of sequence polymorphisms and represent a major selective force toward …

With over 35 million people currently infected, the World Health Organization considers HIV
a global pandemic. HIV is characterized by a high mutation rate, which allows it to evade the …