Infection with the human immunodeficiency virus (HIV) results in a disease characterized by
a rapid viral replication, immunodeficiency and chronic immune activation. The vigorous …

The phrase 'original antigenic sin'was first used to describe the antibody response to
influenza virus. After an initial infection, reinfection with a different strain of the virus boosted …

(57) ABSTRACT A nucleic acid molecule encoding an amino acid sequence consisting of an
agonist of a MHC class I binding native sequence of CEA having an amino acid substitution …

We use mathematical models to determine possible mechanisms contributing to the
evolution and rise of virulent CXCR4–tropic HIV in vivo. The models predict that the ability of …

Tsang, KY, et al., Generation of human cytotoxic T cells Specific for human
carcinoembryonic antigen epitopes from patients immunized with recombinant vaccinia-CEA …

Recent crystallographic results have provided dose to atomic resolution views of the
recognition events mediated by MHC class I molecules. The specificity‐conferring …

P14 mice expressing a transgenic TCR specific for the lymphocytic choriomeningitis virus
glycoprotein p33 epitope were used to study the induction of CTL effector activity by a variety …

Peptide antigens expressed in the thupaus, in combination with self major histocompatibility
complex molecules, play a crucial role in thymocyte selection and shaping of the mature T …

Zika virus (ZIKV) infection is a global health concern due to its association with microcephaly
and neurological complications. The development of a T-cell vaccine is important to combat …

Human immunodeficiency virus (HIV) disease progression is characterised by a slow but
steady decline in the number of CD4+ T cells. It results in the development of AIDS when the …