T cell receptor antagonism in vivo, at last
SC Jameson - Proceedings of the National Academy of …, 1998 - National Acad Sciences
The T cell receptor (TCR) for antigen recognizes a combination of a peptide antigen bound
to a major histocompatibility complex molecule. Providing that the antigen is presented on a …
to a major histocompatibility complex molecule. Providing that the antigen is presented on a …
Could TCR antagonism explain associations between MHC genes and disease?
S Vukmanović, TA Neubert, FR Santori - Trends in Molecular Medicine, 2003 - cell.com
Alleles of major histocompatibility complex (MHC) loci are associated with certain types of
diseases, including those of infectious and autoimmune origin. MHC products can promote …
diseases, including those of infectious and autoimmune origin. MHC products can promote …
Immunopathogenesis of HIV-1 infection
H Cao, BD Walker - Clinics in dermatology, 2000 - cidjournal.com
Human immunodeficiency virus type-1 (HIV-1), the etiologic agent of AIDS, typically elicits
progressive and ultimately profound immunosuppression in untreated persons. Once HIV-1 …
progressive and ultimately profound immunosuppression in untreated persons. Once HIV-1 …
Mutations in a dominant Nef epitope of simian immunodeficiency virus diminish TCR: epitope peptide affinity but not epitope peptide: MHC class I binding
EM Cale, HS Bazick, TA Rianprakaisang… - The Journal of …, 2011 - journals.aai.org
Viruses like HIV and SIV escape from containment by CD8+ T lymphocytes through
generating mutations that interfere with epitope peptide: MHC class I binding. However …
generating mutations that interfere with epitope peptide: MHC class I binding. However …
[图书][B] Strategies for immunointerventions in dermatology
G Burg, RG Dummer - 2012 - books.google.com
Recent progress in the fields of pharmacology and immunology has provided us with new
possibilities for treating dermatological diseases. This book reviews the most important …
possibilities for treating dermatological diseases. This book reviews the most important …
Cytotoxic T-lymphocyte clones specific for an immunodominant epitope display discerning antagonistic response to naturally occurring Epstein-Barr virus variants
R Khanna, SR Burrows, SL Silins, DJ Moss… - Journal of …, 1996 - Am Soc Microbiol
In the present study we have identified Epstein-Barr virus isolates which encode variant
sequences within an HLA B35-restricted immunodominant cytotoxic T-lymphocyte (CTL) …
sequences within an HLA B35-restricted immunodominant cytotoxic T-lymphocyte (CTL) …
Altered peptide ligands: prospects for immune intervention in autoimmune disease
PJ Fairchild - European journal of immunogenetics, 1997 - Wiley Online Library
It has long been accepted that the response of T cells to a protein antigen is strongly
influenced by parameters governing processing and presentation of the immunodominant …
influenced by parameters governing processing and presentation of the immunodominant …
Adaptive evolution of HIV at HLA epitopes is associated with ethnicity in Canada
M Ragonnet-Cronin, S Aris-Brosou, I Joanisse… - PLoS …, 2012 - journals.plos.org
Host immune selection pressure influences the development of mutations that allow for HIV
escape. Mutation patterns induced in HIV by the human leukocyte antigen (HLA) are HLA …
escape. Mutation patterns induced in HIV by the human leukocyte antigen (HLA) are HLA …
Quantitative Analysis of the Antiviral Activity of CD8+ T Cells from Human Immunodeficiency Virus-Positive Asymptomatic Patients with Different Rates of CD4+T-Cell …
R Salerno-Gonçalves, W Lu, JM Andrieu - Journal of virology, 2000 - Am Soc Microbiol
We have measured in 22 asymptomatic human immunodeficiency virus type 1-infected
patients (10 rapid progressors and 12 slow progressors) the proviral load of CD4+ T cells …
patients (10 rapid progressors and 12 slow progressors) the proviral load of CD4+ T cells …
Cytotoxic T-cell antagonism in HIV-1
P Klenerman, R Phillips, A McMichael - Seminars in Virology, 1996 - Elsevier
The cytotoxic T-cell (CTL) response to human immunodeficiency virus Type 1 (HIV-1) is
vigorous and sustained, but despite this, the virus persists. Natural variation arising within …
vigorous and sustained, but despite this, the virus persists. Natural variation arising within …