NETosis and neutrophil extracellular traps in COVID-19: immunothrombosis and beyond

Y Zhu, X Chen, X Liu - Frontiers in Immunology, 2022 - frontiersin.org
Infection with SARS-CoV-2, the causative agent of the Coronavirus disease 2019 (COVID-
19) pandemic, causes respiratory problems and multifaceted organ dysfunction. A crucial …

Neutrophil extracellular traps and long COVID

A Shafqat, MH Omer, I Albalkhi… - Frontiers in …, 2023 - frontiersin.org
Post-acute COVID-19 sequelae, commonly known as long COVID, encompasses a range of
systemic symptoms experienced by a significant number of COVID-19 survivors. The …

Airway dysbiosis accelerates lung function decline in chronic obstructive pulmonary disease

W Liang, Y Yang, S Gong, M Wei, Y Ma, R Feng… - Cell host & …, 2023 - cell.com
Progressive lung function decline is a hallmark of chronic obstructive pulmonary disease
(COPD). Airway dysbiosis occurs in COPD, but whether it contributes to disease progression …

Saracatinib, a selective src kinase inhibitor, blocks fibrotic responses in preclinical models of pulmonary fibrosis

F Ahangari, C Becker, DG Foster… - American Journal of …, 2022 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and often fatal
disorder. Two US Food and Drug Administration–approved antifibrotic drugs, nintedanib and …

[HTML][HTML] The gut-lung axis in severe acute Pancreatitis-associated lung injury: The protection by the gut microbiota through short-chain fatty acids

Z Wang, J Liu, F Li, Y Luo, P Ge, Y Zhang… - Pharmacological …, 2022 - Elsevier
The role of gut microbiota in regulating the intestinal homeostasis, as well as the
pathogenesis of severe acute pancreatitis-associated lung injury (PALI) is widely …

Therapeutic targeting of intestinal fibrosis in Crohn's disease

G Santacroce, MV Lenti, A Di Sabatino - Cells, 2022 - mdpi.com
Intestinal fibrosis is one of the most threatening complications of Crohn's disease. It occurs in
more than a third of patients with this condition, is associated with increased morbidity and …

Neutrophil extracellular traps in airway diseases: Pathological roles and therapeutic implications

A Jo, DW Kim - International Journal of Molecular Sciences, 2023 - mdpi.com
Neutrophils are important effector cells of the innate immune response that fight pathogens
by phagocytosis and degranulation. Neutrophil extracellular traps (NETs) are released into …

Externalized histones fuel pulmonary fibrosis via a platelet-macrophage circuit of TGFβ1 and IL-27

DR Riehl, A Sharma, J Roewe… - Proceedings of the …, 2023 - National Acad Sciences
Externalized histones erupt from the nucleus as extracellular traps, are associated with
several acute and chronic lung disorders, but their implications in the molecular …

Macrophage and neutrophil interactions in the pancreatic tumor microenvironment drive the pathogenesis of pancreatic cancer

HG Pratt, KJ Steinberger, NE Mihalik, S Ott, T Whalley… - Cancers, 2021 - mdpi.com
Simple Summary The survival rates for patients with pancreatic adenocarcinoma are very
low. This dismal prognosis is due in part to late detection and early development of …

METTL3‐mediated N6‐methyladenosine exacerbates ferroptosis via m6A‐IGF2BP2‐dependent mitochondrial metabolic reprogramming in sepsis‐induced acute lung …

H Zhang, D Wu, Y Wang, K Guo… - Clinical and …, 2023 - Wiley Online Library
Neutrophil extracellular traps (NETs), released by polymorphonuclear neutrophils (PMNs),
exert a robust antimicrobial function in infectious diseases such as sepsis. NETs also …