Actions of caffeine in the brain with special reference to factors that contribute to its widespread use

BB Fredholm, K Bättig, J Holmén, A Nehlig… - Pharmacological …, 1999 - ASPET
Caffeine is the most widely consumed behaviorally active substance in the world. Almost all
caffeine comes from dietary sources (beverages and food), most of it from coffee and tea …

Mechanisms of the psychostimulant effects of caffeine: implications for substance use disorders

S Ferré - Psychopharmacology, 2016 - Springer
Background The psychostimulant properties of caffeine are reviewed and compared with
those of prototypical psychostimulants able to cause substance use disorders (SUD) …

Adenosine–dopamine receptor–receptor interactions as an integrative mechanism in the basal ganglia

S Ferré, K Fuxe, BB Fredholm, M Morelli… - Trends in neurosciences, 1997 - cell.com
Increasing evidence suggests that antagonistic interactions between specific subtypes of
adenosine and dopamine receptors in the basal ganglia are involved in the motor …

An update on the mechanisms of the psychostimulant effects of caffeine

S Ferré - Journal of neurochemistry, 2008 - Wiley Online Library
There has been a long debate about the predominant involvement of the different adenosine
receptor subtypes and the preferential role of pre‐versus post‐synaptic mechanisms in the …

Adenosine hypothesis of schizophrenia–opportunities for pharmacotherapy

D Boison, P Singer, HY Shen, J Feldon, BK Yee - Neuropharmacology, 2012 - Elsevier
Pharmacotherapy of schizophrenia based on the dopamine hypothesis remains
unsatisfactory for the negative and cognitive symptoms of the disease. Enhancing N-methyl …

Caffeine—an atypical drug of dependence

JW Daly, BB Fredholm - Drug and alcohol dependence, 1998 - Elsevier
Caffeine is the most widely consumed, behaviorally active substance in the world. Average
caffeine consumption in humans can range in different cultures and nations from 80 to 400 …

Adenosine receptor–dopamine receptor interactions in the basal ganglia and their relevance for brain function

K Fuxe, S Ferré, S Genedani, R Franco, LF Agnati - Physiology & behavior, 2007 - Elsevier
The dopamine D1 and D2 receptors are major receptors in the regulation of striatal function
and striatal adenosine A1 and A2A receptors are major modulators of their signaling. The …

Integrated events in central dopamine transmission as analyzed at multiple levels. Evidence for intramembrane adenosine A2A/dopamine D2 and adenosine A1 …

K Fuxe, S Ferré, M Zoli, LF Agnati - Brain research reviews, 1998 - Elsevier
An analysis at the network and membrane level has provided evidence that antagonistic
interactions between adenosine A2A/dopamine D2 and adenosine A1/dopamine D1 …

Adenosine-dopamine interactions in the ventral striatum Implications for the treatment of schizophrenia: Implications for the treatment of schizophrenia

S Ferré - Psychopharmacology, 1997 - Springer
The ventral striatum is included in brain circuits which connect brain areas classically
ascribed to the motor or to the limbic system. In fact, the ventral striatum is involved in the …

Caffeine and the dopaminergic system

O Cauli, M Morelli - Behavioural pharmacology, 2005 - journals.lww.com
Caffeine is the most widely consumed psychostimulant substance, being self-administered
throughout a wide range of conditions and present in numerous dietary products. Due to its …