International consensus recommendations for the use of prolonged‐infusion beta‐lactam antibiotics: Endorsed by the American College of Clinical Pharmacy, British …
Intravenous β‐lactam antibiotics remain a cornerstone in the management of bacterial
infections due to their broad spectrum of activity and excellent tolerability. β‐lactams are well …
infections due to their broad spectrum of activity and excellent tolerability. β‐lactams are well …
[HTML][HTML] Pharmacokinetics and target attainment of antibiotics in critically ill children: a systematic review of current literature
SJF Hartman, RJ Brüggemann, L Orriëns, N Dia… - Clinical …, 2020 - Springer
Background Pharmacokinetics (PK) are severely altered in critically ill patients due to
changes in volume of distribution (Vd) and/or drug clearance (Cl). This affects the target …
changes in volume of distribution (Vd) and/or drug clearance (Cl). This affects the target …
Augmented renal clearance in pediatric intensive care: are we undertreating our sickest patients?
E Dhont, T Van Der Heggen, A De Jaeger… - Pediatric …, 2020 - Springer
Many critically ill patients display a supraphysiological renal function with enhanced renal
perfusion and glomerular hyperfiltration. This phenomenon described as augmented renal …
perfusion and glomerular hyperfiltration. This phenomenon described as augmented renal …
[HTML][HTML] Pharmacokinetics of antibiotics in pediatric intensive care: fostering variability to attain precision medicine
M Gijsen, D Vlasselaers, I Spriet, K Allegaert - Antibiotics, 2021 - mdpi.com
Children show important developmental and maturational changes, which may contribute
greatly to pharmacokinetic (PK) variability observed in pediatric patients. These PK …
greatly to pharmacokinetic (PK) variability observed in pediatric patients. These PK …
Piperacillin population pharmacokinetics and dosing regimen optimization in critically ill children with normal and augmented renal clearance
A Béranger, S Benaboud, S Urien, F Moulin… - Clinical …, 2019 - Springer
Background Critically ill children frequently display observed alterations of pharmacokinetic
(PK) parameters, leading to a reduction in β-lactam concentrations. This study aimed to …
(PK) parameters, leading to a reduction in β-lactam concentrations. This study aimed to …
Piperacillin-tazobactam in intensive care units: a review of population pharmacokinetic analyses
I El-Haffaf, JA Caissy, A Marsot - Clinical pharmacokinetics, 2021 - Springer
Piperacillin-tazobactam is a potent β-lactam/β-lactamase inhibitor antibiotic commonly
prescribed in the intensive care unit setting. Admitted patients often show large variability in …
prescribed in the intensive care unit setting. Admitted patients often show large variability in …
Relationship between piperacillin concentrations, clinical factors and piperacillin/tazobactam-associated acute kidney injury
S Tang Girdwood, D Hasson… - Journal of …, 2023 - academic.oup.com
Background Piperacillin/tazobactam, a commonly used antibiotic, is associated with acute
kidney injury (AKI). The relationship between piperacillin concentrations and AKI remains …
kidney injury (AKI). The relationship between piperacillin concentrations and AKI remains …
[HTML][HTML] Antibiotics in critically ill children—a narrative review on different aspects of a rational approach
N Bruns, C Dohna-Schwake - Pediatric Research, 2022 - nature.com
Especially critically ill children are exposed to antibiotic overtreatment, mainly caused by the
fear of missing out a severe bacterial infection. Potential adverse effects and selection of …
fear of missing out a severe bacterial infection. Potential adverse effects and selection of …
[HTML][HTML] Optimizing the use of antibiotic agents in the pediatric intensive care unit: a narrative review
J Willems, E Hermans, P Schelstraete, P Depuydt… - Pediatric Drugs, 2021 - Springer
Antibiotics are one of the most prescribed drug classes in the pediatric intensive care unit,
yet the incidence of inappropriate antibiotic prescribing remains high in critically ill children …
yet the incidence of inappropriate antibiotic prescribing remains high in critically ill children …
[HTML][HTML] Beta-Lactams Therapeutic Monitoring in Septic Children–What Target Are We Aiming for? A Scoping Review
R Morales Junior, GO Pereira, GMB Tiguman… - Frontiers in …, 2022 - frontiersin.org
The antimicrobial therapy of sepsis and septic shock should be individualized based on
pharmacokinetic/pharmacodynamic (PK/PD) parameters to deliver effective and timely …
pharmacokinetic/pharmacodynamic (PK/PD) parameters to deliver effective and timely …