[HTML][HTML] Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration
JV Andersen, KH Markussen, E Jakobsen… - …, 2021 - Elsevier
Glutamate is the primary excitatory neurotransmitter of the brain. Cellular homeostasis of
glutamate is of paramount importance for normal brain function and relies on an intricate …
glutamate is of paramount importance for normal brain function and relies on an intricate …
Microglia-mediated neuroinflammation in neurodegenerative diseases
Microglia, being the resident immune cells of the central nervous system, play an important
role in maintaining tissue homeostasis and contributes towards brain development under …
role in maintaining tissue homeostasis and contributes towards brain development under …
[HTML][HTML] Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease
DK Wilton, K Mastro, MD Heller, FW Gergits… - Nature medicine, 2023 - nature.com
Huntington's disease (HD) is a devastating monogenic neurodegenerative disease
characterized by early, selective pathology in the basal ganglia despite the ubiquitous …
characterized by early, selective pathology in the basal ganglia despite the ubiquitous …
[HTML][HTML] Calcium permeable-AMPA receptors and excitotoxicity in neurological disorders
C Guo, YY Ma - Frontiers in neural circuits, 2021 - frontiersin.org
Excitotoxicity is one of the primary mechanisms of cell loss in a variety of diseases of the
central and peripheral nervous systems. Other than the previously established signaling …
central and peripheral nervous systems. Other than the previously established signaling …
A genetically encoded fluorescent sensor for in vivo imaging of GABA
Current techniques for monitoring GABA (γ-aminobutyric acid), the primary inhibitory
neurotransmitter in vertebrates, cannot follow transients in intact neural circuits. To develop …
neurotransmitter in vertebrates, cannot follow transients in intact neural circuits. To develop …
Treating early postnatal circuit defect delays Huntington's disease onset and pathology in mice
BY Braz, D Wennagel, L Ratié, DAR de Souza… - Science, 2022 - science.org
Recent evidence has shown that even mild mutations in the Huntingtin gene that are
associated with late-onset Huntington's disease (HD) disrupt various aspects of human …
associated with late-onset Huntington's disease (HD) disrupt various aspects of human …
[HTML][HTML] Extrasynaptic NMDA receptor involvement in central nervous system disorders
MP Parsons, LA Raymond - Neuron, 2014 - cell.com
NMDA receptor (NMDAR)-induced excitotoxicity is thought to contribute to the cell death
associated with certain neurodegenerative diseases, stroke, epilepsy, and traumatic brain …
associated with certain neurodegenerative diseases, stroke, epilepsy, and traumatic brain …
[HTML][HTML] Molecular pathophysiological mechanisms in Huntington's disease
A Jurcau - Biomedicines, 2022 - mdpi.com
Huntington's disease is an inherited neurodegenerative disease described 150 years ago
by George Huntington. The genetic defect was identified in 1993 to be an expanded CAG …
by George Huntington. The genetic defect was identified in 1993 to be an expanded CAG …
Huntington's disease: underlying molecular mechanisms and emerging concepts
J Labbadia, RI Morimoto - Trends in biochemical sciences, 2013 - cell.com
Huntington's disease (HD) is a progressive neurodegenerative disorder for which no
disease modifying treatments exist. Many molecular changes and cellular consequences …
disease modifying treatments exist. Many molecular changes and cellular consequences …
[HTML][HTML] Acetylcholinesterase inhibitors in the treatment of neurodegenerative diseases and the role of acetylcholinesterase in their pathogenesis
ŁJ Walczak-Nowicka, M Herbet - International journal of molecular …, 2021 - mdpi.com
Acetylcholinesterase (AChE) plays an important role in the pathogenesis of
neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative …
neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative …