Ketamine, a racemic mixture consisting of (S)-and (R)-ketamine, has been in clinical use
since 1970. Although best characterized for its dissociative anesthetic properties, ketamine …

Ketamine is a promising therapeutic option in treatment-resistant depression (TRD). The
acute efficacy of ketamine in TRD has been demonstrated in replicated randomised …

Ketamine has rapid yet often transient antidepressant effects in patients with treatment-
resistant depression. Different strategies have been proposed to prolong these effects …

This is the first systematic review of the safety of ketamine in the treatment of depression
after single and repeated doses. We searched MEDLINE, PubMed, PsycINFO, and …

Background Over the past 2 decades, the use of intravenous ketamine infusions as a
treatment for chronic pain has increased dramatically, with wide variation in patient …

Importance Several studies now provide evidence of ketamine hydrochloride's ability to
produce rapid and robust antidepressant effects in patients with mood and anxiety disorders …

BackgroundKetamine and non-ketamine N-methyl-d-aspartate receptor antagonists
(NMDAR antagonists) recently demonstrated antidepressant efficacy for the treatment of …

Objective: The authors conducted a systematic review and meta-analysis of ketamine and
other N-methyl-d-aspartate (NMDA) receptor antagonists in the treatment of major …

Ketamine is the prototype for a new generation of glutamate-based antidepressants that
rapidly alleviate depression within hours of treatment. Over the past decade, there has been …

Background: At least 10-20% of the patients suffering from depression meet criteria for
treatment-resistant depression (TRD). In the last decades, an important role of glutamate in …