Quantitation of enantiomers of r-7, t-8, 9, c-10-tetrahydroxy-7, 8, 9, 10-tetrahydrobenzo [a]-pyrene in human urine: evidence supporting metabolic activation of benzo [a …
SS Hecht, JB Hochalter - Mutagenesis, 2014 - academic.oup.com
Abstract Benzo [a] pyrene (BaP), a potent polycyclic aromatic hydrocarbon carcinogen, is
widely distributed in the human environment. All humans are exposed to BaP through the …
widely distributed in the human environment. All humans are exposed to BaP through the …
Data-independent-acquisition mass spectrometry for identification of targeted-peptide site-specific modifications
CJ Porter, MS Bereman - Analytical and bioanalytical chemistry, 2015 - Springer
We present a novel strategy based on data-independent acquisition coupled to targeted
data extraction for the detection and identification of site-specific modifications of targeted …
data extraction for the detection and identification of site-specific modifications of targeted …
Applying tobacco, environmental, and dietary-related biomarkers to understand cancer etiology and evaluate prevention strategies
LA Peterson, S Balbo, N Fujioka, DK Hatsukami… - … Biomarkers & Prevention, 2020 - AACR
Many human cancers are caused by environmental and lifestyle factors. Biomarkers of
exposure and risk developed by our team have provided critical data on internal exposure to …
exposure and risk developed by our team have provided critical data on internal exposure to …
Refinement of a methodology for untargeted detection of serum albumin adducts in human populations
GW Preston, M Plusquin, O Sozeri… - Chemical research in …, 2017 - ACS Publications
Covalently modified blood proteins (eg, serum albumin adducts) are increasingly being
viewed as potential biomarkers via which the environmental causes of human diseases may …
viewed as potential biomarkers via which the environmental causes of human diseases may …
Benzo (a) pyrene represses melanogenesis in B16F10 mouse melanoma cells
DH Joo, HJ Cha, K Kim, M Jung, JM Ko, IS An… - Molecular & Cellular …, 2015 - Springer
Abstract Benzo (a) pyrene (BaP) is a chemically based polycyclic aromatic hydrocarbon
(PAH) that is readily absorbed by the skin. BaP is metabolized to BaP-diol-epoxide by …
(PAH) that is readily absorbed by the skin. BaP is metabolized to BaP-diol-epoxide by …
[HTML][HTML] Smoking history decreases survival in patients with squamous cell carcinoma of the mouth: A retrospective study with 15 years of follow-up
N Colares, DFS Rodrigues, MO Freitas… - Asian Pacific Journal …, 2019 - ncbi.nlm.nih.gov
Background: The purpose of this study was to evaluate the influence of smoking history on
the clinical-pathological, sociodemographic and prognostic characteristics of patients with …
the clinical-pathological, sociodemographic and prognostic characteristics of patients with …
[PDF][PDF] The effect of benzo [a] pyrene on metabolic activation of anticancer drug ellipticine in mice
M Stiborova, V Cerna, M Moserova, VM Arlt, E Frei - Neuro Endocrinol Lett, 2013 - nel.edu
OBJECTIVES: The aim of this study was to investigate a role of cytochrome P450 (CYP) and
peroxidase in ellipticine oxidative activation in two mouse strains differing in expression of …
peroxidase in ellipticine oxidative activation in two mouse strains differing in expression of …
Polymorphism rs3819102 in thymidylate synthase and environmental factors: effects on lung cancer in Chinese population
W Feng, X Guo, H Huang, C Xu, Y Li, S Guo… - Current Problems in …, 2019 - Elsevier
Purpose Lung cancer is the leading cause of cancer death worldwide, and the predominant
risk factor for its development is smoking. Thymidylate synthase (TYMS) is a key enzyme in …
risk factor for its development is smoking. Thymidylate synthase (TYMS) is a key enzyme in …
[PDF][PDF] Paternal smoking in relation to sperm quality and intracytoplasmic sperm injection outcomes
H Amor, S Nyaz, ME Hammadeh - International Journal of Women's …, 2019 - ijwhr.net
Objectives: The present study focused on tobacco smoke and its effect on semen
parameters, sperm DNA quality (compaction and fragmentation) and clinical outcomes after …
parameters, sperm DNA quality (compaction and fragmentation) and clinical outcomes after …