An update on diagnostic and prognostic biomarkers for traumatic brain injury

KK Wang, Z Yang, T Zhu, Y Shi… - Expert review of …, 2018 - Taylor & Francis
Introduction: Traumatic brain injury (TBI) is a major worldwide neurological disorder of
epidemic proportions. To date, there are still no FDA-approved therapies to treat any forms …

[HTML][HTML] Traumatic brain injury and Alzheimer's disease: the cerebrovascular link

J Ramos-Cejudo, T Wisniewski, C Marmar… - …, 2018 - thelancet.com
Traumatic brain injury (TBI) and Alzheimer's disease (AD) are devastating neurological
disorders, whose complex relationship is not completely understood. Cerebrovascular …

[HTML][HTML] Optical imaging and spectroscopy for the study of the human brain: status report

H Ayaz, WB Baker, G Blaney, DA Boas… - …, 2022 - spiedigitallibrary.org
This report is the second part of a comprehensive two-part series aimed at reviewing an
extensive and diverse toolkit of novel methods to explore brain health and function. While …

Cerebrovascular reactivity (CVR) MRI with CO2 challenge: a technical review

P Liu, B Jill, H Lu - Neuroimage, 2019 - Elsevier
Cerebrovascular reactivity (CVR) is an indicator of cerebrovascular reserve and provides
important information about vascular health in a range of brain conditions and diseases …

Pathophysiology of traumatic brain injury

KJ Dixon - Physical Medicine and Rehabilitation Clinics, 2017 - pmr.theclinics.com
Traumatic brain injury (TBI) may have many different causes, including a blow to the head,
penetration of the skull, fast acceleration or deceleration of the head, or exposure to a blast …

Response of the cerebral vasculature following traumatic brain injury

A Salehi, JH Zhang, A Obenaus - Journal of Cerebral Blood …, 2017 - journals.sagepub.com
The critical role of the vasculature and its repair in neurological disease states is beginning
to emerge particularly for stroke, dementia, epilepsy, Parkinson's disease, tumors and …

Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model

CA Tagge, AM Fisher, OV Minaeva… - Brain, 2018 - academic.oup.com
The mechanisms underpinning concussion, traumatic brain injury, and chronic traumatic
encephalopathy, and the relationships between these disorders, are poorly understood. We …

Monocyte-derived IL-6 programs microglia to rebuild damaged brain vasculature

BR Choi, KR Johnson, D Maric, DB McGavern - Nature immunology, 2023 - nature.com
Cerebrovascular injury (CVI) is a common pathology caused by infections, injury, stroke,
neurodegeneration and autoimmune disease. Rapid resolution of a CVI requires a …

A framework to advance biomarker development in the diagnosis, outcome prediction, and treatment of traumatic brain injury

EA Wilde, IB Wanner, K Kenney, J Gill… - Journal of …, 2022 - liebertpub.com
Multi-modal biomarkers (eg, imaging, blood-based, physiological) of unique traumatic brain
injury (TBI) endophenotypes are necessary to guide the development of personalized and …

Traumatic microbleeds suggest vascular injury and predict disability in traumatic brain injury

AD Griffin, LC Turtzo, GY Parikh, A Tolpygo, Z Lodato… - Brain, 2019 - academic.oup.com
Traumatic microbleeds are small foci of hypointensity seen on T2*-weighted MRI in patients
following head trauma that have previously been considered a marker of axonal injury. The …