Epigenetic tools (The Writers, The Readers and The Erasers) and their implications in cancer therapy
S Biswas, CM Rao - European journal of pharmacology, 2018 - Elsevier
Addition of chemical tags on the DNA and modification of histone proteins impart a distinct
feature on chromatin architecture. With the advancement in scientific research, the key …
feature on chromatin architecture. With the advancement in scientific research, the key …
[HTML][HTML] DNA methylation and its basic function
LD Moore, T Le, G Fan - Neuropsychopharmacology, 2013 - nature.com
In the mammalian genome, DNA methylation is an epigenetic mechanism involving the
transfer of a methyl group onto the C5 position of the cytosine to form 5-methylcytosine. DNA …
transfer of a methyl group onto the C5 position of the cytosine to form 5-methylcytosine. DNA …
[HTML][HTML] METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancer
B Yue, C Song, L Yang, R Cui, X Cheng, Z Zhang… - Molecular cancer, 2019 - Springer
Background As one of the most frequent chemical modifications in eukaryotic mRNAs, N6-
methyladenosine (m6A) modification exerts important effects on mRNA stability, splicing …
methyladenosine (m6A) modification exerts important effects on mRNA stability, splicing …
[HTML][HTML] In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions
S Quenneville, G Verde, A Corsinotti, A Kapopoulou… - Molecular cell, 2011 - cell.com
The maintenance of H3K9 and DNA methylation at imprinting control regions (ICRs) during
early embryogenesis is key to the regulation of imprinted genes. Here, we reveal that ZFP57 …
early embryogenesis is key to the regulation of imprinted genes. Here, we reveal that ZFP57 …
Basic concepts of epigenetics: impact of environmental signals on gene expression
EA Mazzio, KFA Soliman - Epigenetics, 2012 - Taylor & Francis
Through epigenetic modifications, specific long-term phenotypic consequences can arise
from environmental influence on slowly evolving genomic DNA. Heritable epigenetic …
from environmental influence on slowly evolving genomic DNA. Heritable epigenetic …
Role of Tet1 and 5-hydroxymethylcytosine in cocaine action
Ten-eleven translocation (TET) enzymes mediate the conversion of 5-methylcytosine (5mC)
to 5-hydroxymethylcytosine (5hmC), which is enriched in brain, and its ultimate DNA …
to 5-hydroxymethylcytosine (5hmC), which is enriched in brain, and its ultimate DNA …
Cys2His2 zinc finger protein family: classification, functions, and major members
SV Razin, VV Borunova, OG Maksimenko… - Biochemistry …, 2012 - Springer
Abstract Cys2His2 (C2H2)-type zinc fingers are widespread DNA binding motifs in
eukaryotic transcription factors. Zinc fingers are short protein motifs composed of two or …
eukaryotic transcription factors. Zinc fingers are short protein motifs composed of two or …
Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer
The human POK family members are transcription factors with a POZ domain and zinc-
fingers that act primarily as transcriptional repressors. Several members of this family are …
fingers that act primarily as transcriptional repressors. Several members of this family are …
Evolving insights on how cytosine methylation affects protein–DNA binding
Many anecdotal observations exist of a regulatory effect of DNA methylation on gene
expression. However, in general, the underlying mechanisms of this effect are poorly …
expression. However, in general, the underlying mechanisms of this effect are poorly …
The physics of epigenetics
In higher organisms, all cells share the same genome, but every cell expresses only a
limited and specific set of genes that defines the cell type. During cell division, not only the …
limited and specific set of genes that defines the cell type. During cell division, not only the …