Foreign particles and cells are cleared from the body by phagocytes that must also
recognize and avoid clearance of" self" cells. The membrane protein CD47 is reportedly a" …

Spontaneous intracerebral hemorrhage (ICH) is a particularly severe type of stroke for which
no specific treatment has been established yet. Although preclinical models of ICH have …

Nuclear medicine imaging has been developed as a powerful diagnostic approach for
cancers by detecting gamma rays directly or indirectly from radionuclides to construct …

Inclusion of a tumor-targeting molecule in nanosized delivery systems increases their in vivo
efficacy. However, the biodistribution and pharmacokinetics of the uptake of such particles …

Lysosomes and lysosomal enzymes play a central role in numerous cellular processes,
including cellular nutrition, recycling, signaling, defense, and cell death. Genetic deficiencies …

Inflammation is a highly dynamic and complex adaptive process to preserve and restore
tissue homeostasis. Originally viewed as an immune-privileged organ, the central nervous …

The use of drug delivery systems (DDS) is an attractive approach to facilitate uptake of
therapeutic agents at the desired site of action, particularly when free drug has poor …

Therapeutic targeting of the immune system, including chimeric antigen receptor-T cell
therapy, immune checkpoint blockade therapy, neoantigen vaccines, and small molecule …

Targeted nanomedicine holds promise to find clinical use in many medical areas.
Endothelial cells that line the luminal surface of blood vessels represent a key target for …

Positron emission tomography (PET) has become a vital imaging modality in the diagnosis
and treatment of disease, most notably cancer. A wide array of small molecule PET …