Current knowledge and trends in age-related macular degeneration: genetics, epidemiology, and prevention

R Velez-Montoya, SCN Oliver, JL Olson, SL Fine… - Retina, 2014 - journals.lww.com
Purpose: To address the most dynamic and current issues concerning human genetics, risk
factors, pharmacoeconomics, and prevention regarding age-related macular degeneration …

Association between vitamin D and age-related macular degeneration in the Third National Health and Nutrition Examination Survey, 1988 through 1994

N Parekh, RJ Chappell, AE Millen… - Archives of …, 2007 - jamanetwork.com
Objective To evaluate the associations between levels of vitamin D (25-hydroxyvitamin D) in
serum and prevalent age-related macular degeneration (AMD). Methods and Design Cross …

Evidence of association of APOE with age‐related macular degeneration ‐ a pooled analysis of 15 studies

GJ McKay, CC Patterson, U Chakravarthy… - Human …, 2011 - Wiley Online Library
Age‐related macular degeneration (AMD) is the most common cause of incurable visual
impairment in high‐income countries. Previous studies report inconsistent associations …

Overexpression of HTRA1 leads to ultrastructural changes in the elastic layer of Bruch's membrane via cleavage of extracellular matrix components

S Vierkotten, PS Muether, S Fauser - PloS one, 2011 - journals.plos.org
Variants in the chromosomal region 10q26 are strongly associated with an increased risk for
age-related macular degeneration (AMD). Two potential AMD genes are located in this …

[HTML][HTML] Age-related macular degeneration: genetic and environmental factors of disease

Y Chen, M Bedell, K Zhang - Molecular interventions, 2010 - ncbi.nlm.nih.gov
Age-related macular degeneration (AMD) is the most common cause of visual impairment
among the elderly in developed countries, and its prevalence is thus increasing as the …

Optical coherence tomography angiography of dry age-related macular degeneration

NK Waheed, EM Moult, JG Fujimoto… - OCT Angiography in …, 2016 - karger.com
Optical coherence tomography angiography (OCTA) can be used to visualize alterations in
the choriocapillaris of patients with dry age-related macular degeneration (AMD). These …

Five-year incidence, progression, and risk factors for age-related macular degeneration: the age, gene/environment susceptibility study

F Jonasson, DE Fisher, G Eiriksdottir, S Sigurdsson… - Ophthalmology, 2014 - Elsevier
Objective To investigate the incidence and progression of age-related macular degeneration
(AMD) and associated risk factors. Design Population-based, prospective, cohort study …

Immunopathological aspects of age-related macular degeneration

M Patel, CC Chan - Seminars in immunopathology, 2008 - Springer
Age-related macular degeneration (AMD) represents a leading cause of blindness
worldwide. While the clinical and histopathological aspects of AMD are well characterized …

Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-α-lipoic acid

L Jia, Z Liu, L Sun, SS Miller, BN Ames… - … & visual science, 2007 - iovs.arvojournals.org
purpose. To understand better the cell and molecular basis for the epidemiologic
association between cigarette smoke, oxidant injury, and age-associated macular …

Cardiovascular disease and hypertension are strong risk factors for choroidal neovascularization

RE Hogg, JV Woodside, SECM Gilchrist, R Graydon… - Ophthalmology, 2008 - Elsevier
PURPOSE: To investigate the association of cardiovascular risk factors and inflammatory
markers with neovascular age-related macular degeneration (AMD). DESIGN: Cross …