There is growing evidence that the remodeling of cerebral microvessels plays an important
role in plastic changes in the brain associated with development, experience, learning, and …

To characterize the influence of apolipoprotein-E (APOE) genotype on cerebral Aβ load and
longitudinal Aβ trajectories,[11 C] Pittsburgh compound-B (PiB) positron emission …

Background: Subjective cognitive decline (SCD) may be an early manifestation of pre-
clinical Alzheimer's disease. Elevated amyloid-β (Aβ) is a correlate of SCD symptoms in …

Automated segmentation of the aging brain raises significant challenges because of the
prevalence, extent, and heterogeneity of white matter hyperintensities. White matter …

Introduction: Early-life educational attainment contributes to cognitive reserve (CR). We
investigated the associations of lifelong CR with dementia and mild cognitive impairment …

A true understanding of the distribution and functional correlates of Alzheimer's disease
pathology in dementia-free older adults requires a population-based perspective. Here we …

Introduction A data‐driven index of dementia risk based on magnetic resonance imaging
(MRI), the Alzheimer's Disease Pattern Similarity (AD‐PS) score, was estimated for …

Background and purpose: Poststroke cognitive impairment (PSCI) is common, but the impact
of β-amyloid (Aβ) on PSCI is uncertain. The proposed study will investigate amyloid …

Background Early-life educational attainment represents a major proxy for cognitive reserve
(CR) that could benefit late-life cognitive function. We sought to investigate the associations …

Mild cognitive impairment (MCI) as a clinical entity was proposed by a research group led by
Dr Ronald Petersen in 1999 (Petersen, et al., 1999). MCI in terms of its etiology, pathology …