Hippocampus: molecular, cellular, and circuit features in anxiety
HJ Shi, S Wang, XP Wang, RX Zhang, LJ Zhu - Neuroscience bulletin, 2023 - Springer
Anxiety disorders are currently a major psychiatric and social problem, the mechanisms of
which have been only partially elucidated. The hippocampus serves as a major target of …
which have been only partially elucidated. The hippocampus serves as a major target of …
Ketamine as a prophylactic resilience-enhancing agent
AG Evers, JW Murrough, DS Charney… - Frontiers in Psychiatry, 2022 - frontiersin.org
Stress exposure is one of the greatest risk factors for psychiatric illnesses, including major
depressive disorder (MDD) and posttraumatic stress disorder (PTSD). Enhancing stress …
depressive disorder (MDD) and posttraumatic stress disorder (PTSD). Enhancing stress …
Hippocampal GABAergic interneurons and their co-localized neuropeptides in stress vulnerability and resilience
A Albrecht, E Redavide, S Regev-Tsur, O Stork… - Neuroscience & …, 2021 - Elsevier
Studies in humans and rodents suggest a critical role for the hippocampal formation in
cognition and emotion, but also in the adaptation to stressful events. Successful stress …
cognition and emotion, but also in the adaptation to stressful events. Successful stress …
Sex differences in the sustained effects of ketamine on resilience to chronic stress
T Okine, R Shepard, E Lemanski… - Frontiers in behavioral …, 2020 - frontiersin.org
Exposure to stress is recognized to be a triggering factor in several mood disorders,
including depression and anxiety. There is very little understanding of why female subjects …
including depression and anxiety. There is very little understanding of why female subjects …
The role of BDNF in mediating the prophylactic effects of (R, S)-ketamine on fear generalization and extinction
JD Ryan, N Tse, C Huang, R Yang, FS Lee - Translational psychiatry, 2022 - nature.com
Fear generalization is a conserved survival mechanism that can become maladaptive in the
face of traumatic situations, a feature central to certain anxiety disorders including …
face of traumatic situations, a feature central to certain anxiety disorders including …
[HTML][HTML] Ketamine, but not guanosine, as a prophylactic agent against corticosterone-induced depressive-like behavior: possible role of long-lasting pro-synaptogenic …
A Camargo, AP Dalmagro, MM de Souza… - Experimental …, 2020 - Elsevier
Ketamine has been reported to exert a prophylactic effect against stress-induced depressive-
like behavior by modulating the guanosine-based purinergic system. However, the …
like behavior by modulating the guanosine-based purinergic system. However, the …
Short daily exposure to environmental enrichment, fluoxetine, or their combination reverses deterioration of the coat and anhedonia behaviors with differential effects …
GB Ramírez-Rodríguez, NM Vega-Rivera… - International Journal of …, 2021 - mdpi.com
Depression is a neuropsychiatric disorder with a high impact on the worldwide population.
To overcome depression, antidepressant drugs are the first line of treatment. However, pre …
To overcome depression, antidepressant drugs are the first line of treatment. However, pre …
Hippocampal subgranular zone FosB expression is critical for neurogenesis and learning
CE Manning, AL Eagle, CC Kwiatkowski, R Achargui… - Neuroscience, 2019 - Elsevier
Neural proliferation in the dentate gyrus (DG) is closely linked with learning and memory, but
the transcriptional programming that drives adult proliferation remains incompletely …
the transcriptional programming that drives adult proliferation remains incompletely …
Hippocampal Inflammation and Gene Expression Changes in Peripheral Lipopolysaccharide Challenged Mice Showing Sickness and Anxiety-Like Behaviors
S Matsuura, Y Nishimoto, A Endo, H Shiraki… - Biological and …, 2023 - jstage.jst.go.jp
Neuroinflammation is often associated with the development of depressive and anxiety
disorders. The hippocampus is one of the brain regions affected by inflammation that is …
disorders. The hippocampus is one of the brain regions affected by inflammation that is …
NRSF deficiency leads to abnormal postnatal development of dentate gyrus and impairment of progenitors in subgranular zone of hippocampus
YC Wang, P Liu, LY Yue, F Huang, YX Xu… - …, 2021 - Wiley Online Library
Neuron‐restrictive silencing factor (NRSF) is a zinc‐finger transcription factor that regulates
expression of a diverse set of genes. However, NRSF function in brain development still …
expression of a diverse set of genes. However, NRSF function in brain development still …