Plague is a vector-borne disease caused by Yersinia pestis. Transmitted by fleas from
rodent reservoirs, Y. pestis emerged< 6000 years ago from an enteric bacterial ancestor …

Yersinia pestis, the bacterial causative agent of plague, remains an important threat to
human health. Plague is a rodent-borne disease that has historically shown an outstanding …

Inhalation of the bacterium Yersinia pestis results in primary pneumonic plague. Pneumonic
plague is the most severe manifestation of plague, with mortality rates approaching 100% in …

Inflammasome assembly activates caspase-1 and initiates the inflammatory cell death
program pyroptosis, which is protective against numerous pathogens. Consequently …

Legume–rhizobium pairs are often observed that produce symbiotic root nodules but fail to
fix nitrogen. Using the Sinorhizobium meliloti and Medicago truncatula symbiotic system, we …

Abstract Background The human pathogen Haemophilus influenzae was the main cause of
bacterial meningitis in children and a major cause of worldwide infant mortality before the …

Inhalation of Yersinia pestis causes primary pneumonic plague, a highly lethal syndrome
with mortality rates approaching 100%. Pneumonic plague progression is biphasic, with an …

The series of events that occurs immediately after pathogen entrance into the body is largely
speculative. Key aspects of these events are pathogen dissemination and pathogen …

In the context of pulmonary infection, both hosts and pathogens have evolved a multitude of
mechanisms to regulate the process of host cell death. The host aims to rapidly induce an …

In order to survive inside the host cell, bacterial pathogens have evolved a variety of
mechanisms to avoid or interfere with innate immune defenses. Several reports have shown …