Insights into the Evolving Epidemiology of Clostridioides difficile Infection and Treatment: A Global Perspective

C Liu, T Monaghan, A Yadegar, T Louie, D Kao - Antibiotics, 2023 - mdpi.com
Clostridioides difficile remains an important public health threat, globally. Since the
emergence of the hypervirulent strain, ribotype 027, new strains have been reported to …

Alternatives therapeutic approaches to conventional antibiotics: Advantages, limitations and potential application in medicine

H Alaoui Mdarhri, R Benmessaoud, H Yacoubi, L Seffar… - Antibiotics, 2022 - mdpi.com
Resistance to antimicrobials and particularly multidrug resistance is one of the greatest
challenges in the health system nowadays. The continual increase in the rates of …

Foodborne Clostridioides Species: Pathogenicity, Virulence and Biocontrol Options

M Garvey - Microorganisms, 2023 - mdpi.com
Clostridioides species possess many virulence factors and alarming levels of muti-drug
resistance which make them a significant risk to public health safety and a causative agent …

Clostridioides difficile S-Layer Protein A (SlpA) serves as a general phage receptor

ALM Royer, AA Umansky, MM Allen… - Microbiology …, 2023 - Am Soc Microbiol
Therapeutic bacteriophages (phages) are being considered as alternatives in the fight
against Clostridioides difficile infections. To be efficient, phages should have a wide host …

Biofilm Formation of Clostridioides difficile, Toxin Production and Alternatives to Conventional Antibiotics in the Treatment of CDI

LMT Dicks - Microorganisms, 2023 - mdpi.com
Clostridioides difficile is considered a nosocomial pathogen that flares up in patients
exposed to antibiotic treatment. However, four out of ten patients diagnosed with C. difficile …

[HTML][HTML] A novel chimeric endolysin with enhanced lytic and binding activity against Clostridium perfringens

Y Choi, E Ha, M Kong, S Ryu - LWT, 2023 - Elsevier
Clostridium perfringens is a gram-positive, anaerobic, and spore-forming bacterium that
produces toxins causing various diseases in humans and livestock animals. With the growth …

Gut Microbiota–Gut Metabolites and Clostridioides difficile Infection: Approaching Sustainable Solutions for Therapy

B Gurung, M Stricklin, S Wang - Metabolites, 2024 - mdpi.com
Clostridioides difficile (C. difficile) infection (CDI) is the most common hospital-acquired
infection. With the combination of a high rate of antibiotic resistance and recurrence, it has …

Necrotic enteritis and antibiotic-free production of broiler chickens: Challenges in testing and using alternative products

RJ Moore - Animal Nutrition, 2023 - Elsevier
The global trend towards raising broiler chickens without the use of in-feed antibiotics (IFAs)
means that there is an ongoing need to develop alternative treatments capable of delivering …

Post-infectious ibs following Clostridioides difficile infection; role of microbiota and implications for treatment

D Taghaddos, Z Saqib, X Bai, P Bercik… - Digestive and Liver …, 2024 - Elsevier
Up to 25% of patients recovering from antibiotic-treated Clostridioides difficile infection (CDI)
develop functional symptoms reminiscent of Post-Infectious Irritable Bowel Syndrome (PI …

Future of Engineered Phage Therapy for Clostridium difficile Infections

A Nubgan - Al-Rafidain Journal of Medical Sciences (ISSN 2789 …, 2023 - ajms.iq
Bacteriophages have the potential to eliminate both antibiotic-resistant and sensitive
bacteria; as a result, they have become a major focus of such research. In contrast to …