miRNAs role in cervical cancer pathogenesis and targeted therapy: Signaling pathways interplay

AS Doghish, MA Ali, SS Elyan, MA Elrebehy… - … -Research and Practice, 2023 - Elsevier
Cervical cancer (CC) is the primary cause of cancer deaths in underdeveloped countries.
The persistence of infection with high-risk human papillomavirus (HPV) is a significant …

Non-coding RNA-based therapeutics in cancer therapy: An emphasis on Wnt/β-catenin control

A Taheriazam, SD Bayanzadeh, MH Farahani… - European Journal of …, 2023 - Elsevier
Non-coding RNA transcripts are RNA molecules that have mainly regulatory functions and
they do not encode proteins. microRNAs (miRNAs), lncRNAs and circRNAs are major types …

[HTML][HTML] Role and Dysregulation of miRNA in Patients with Parkinson's Disease

M Salemi, G Marchese, G Lanza, FII Cosentino… - International Journal of …, 2022 - mdpi.com
Parkinson's disease (PD) is a neurodegenerative synucleinopathy that has a not yet fully
understood molecular pathomechanism behind it. The role of risk genes regulated by small …

[HTML][HTML] Protective role of circRNA CCND1 in ulcerative colitis via miR-142-5p/NCOA3 axis

P Xiang, T Ge, J Zhou, Y Zhang - BMC gastroenterology, 2023 - Springer
Background Increasing research indicates that circular RNAs (circRNAs) play critical roles in
the development of ulcerative colitis (UC). This study aimed to determine the role of circRNA …

Exosomal miRNAs assist in the crosstalk between tumor cells and immune cells and its potential therapeutics

X Chen, Y Li, M Li, Y Xie, K Wang, L Zhang, Z Zou… - Life Sciences, 2023 - Elsevier
Exosomes are small extracellular vesicles that carry active substances (including proteins,
lipids, and nucleic acids) and are essential for homeostasis and signal transmission. Recent …

[HTML][HTML] Interaction of cervical microbiome with epigenome of epithelial cells: Significance of inflammation to primary healthcare

V Holubekova, Z Kolkova, I Kasubova… - Biomolecular …, 2022 - degruyter.com
One pillar of the predictive, preventive, and personalized medicine framework strategies is
the female health. The evaluation of women's lifestyle and dietary habits in context with …

miR‐142‐3p/5p role in cancer: From epigenetic regulation to immunomodulation

P Zareifar, HM Ahmed, P Ghaderi… - Cell Biochemistry …, 2024 - Wiley Online Library
MicroRNAs (miRNAs) play critical roles in cancer pathobiology, acting as regulators of gene
expression and pivotal drivers of tumorigenesis. It is believed that miRNAs act through …

Th17 cells target the metabolic miR‐142‐5p–succinate dehydrogenase subunit C/D (SDHC/SDHD) axis, promoting invasiveness and progression of cervical cancers

M Pohlers, S Gies, T Taenzer, R Stroeder… - Molecular …, 2023 - Wiley Online Library
During cervical carcinogenesis, T‐helper (Th)‐17 cells accumulate in the peripheral blood
and tumor tissues of cancer patients. We previously demonstrated that Th17 cells are …

A novel frameshift variant of LMX1A that leads to autosomal dominant non-syndromic sensorineural hearing loss: functional characterization of the C-terminal domain …

M Xiao, Y Zheng, KH Huang, S Yu… - Human Molecular …, 2023 - academic.oup.com
Non-syndromic sensorineural hearing loss (NSHL) is a group of genetically heterogeneous
conditions with broad phenotypic heterogeneity. There is, at present, no curative treatment …

[HTML][HTML] Novel_circ_003686 regulates the osteogenic differentiation of MSCs in patients with myeloma bone disease through miR-142-5p/IGF1 axis

L Qiu, L Ma, D Chen, N Zhang, J Cai, Q Zhang… - Journal of Bone …, 2023 - Elsevier
Objectives Circ_003686 is a novel_circRNA with abnormally low expression found in the
samples of multiple myeloma bone disease (MBD) patients. The current research intended …