The JAK/STAT signaling pathway is an universally expressed intracellular signal
transduction pathway and involved in many crucial biological processes, including cell …

Proinflammatory cytokine activation of the Janus kinase/signal transducers and activators of
transcription (JAK/STAT) signal transduction pathway is a critical event in the pathogenesis …

S100A9/S100A8 (calprotectin), a member of the S100 protein family, has been shown to
play a pivotal role in innate immunity activation. Calprotectin plays a critical role in the …

Lipid nanoparticles hold great potential as an effective non-viral vector for nucleic acid-
based gene therapy. Plasmid DNA delivery can result in extended transgene expression …

Extracellular signal-regulated kinase (ERK) is a member of the mitogen-activated protein
kinase family of signaling molecules. ERK is predominantly found in two forms, ERK1 (p44) …

Abstract Matrix metalloproteinases (MMPs), A Disintegrin and Metalloproteinase (ADAM)
and A Disintegrin and Metalloproteinase with Thrombospondin Motif (ADAMTS) are zinc …

PI3K/Akt/mTOR signaling regulates diverse cellular processes. Abnormal PI3K/Akt/mTOR
signaling is a characteristic feature of cancer. As such inhibition of PI3K/Akt/mTOR signaling …

Matrix metalloproteinases (MMPs) are zinc-dependent enzymes. These enzymes play a
critical role in the destruction of articular cartilage in rheumatoid arthritis (RA), osteoarthritis …

Studies have demonstrated that protease-activated receptors (PARs) with four subtypes
(PAR1-4) are mainly expressed in the renal epithelial, endothelial, and podocyte cells …

Parkinson's disease (PD) is a neurodegenerative disorder in which inflammation and
oxidative stress play key etiopathological role. The pathology of PD brain is characterized by …