The molecular principles of gene regulation by Polycomb repressive complexes
NP Blackledge, RJ Klose - Nature reviews Molecular cell biology, 2021 - nature.com
Precise control of gene expression is fundamental to cell function and development.
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …
Although ultimately gene expression relies on DNA-binding transcription factors to guide the …
Epigenetic balance of gene expression by Polycomb and COMPASS families
A Piunti, A Shilatifard - Science, 2016 - science.org
BACKGROUND Multicellular organisms depend on the precise orchestration of gene
expression to direct embryonic development and to maintain tissue homeostasis through …
expression to direct embryonic development and to maintain tissue homeostasis through …
Th2 cells in health and disease
T Nakayama, K Hirahara, A Onodera… - Annual review of …, 2017 - annualreviews.org
Helper T (Th) cell subsets direct immune responses by producing signature cytokines. Th2
cells produce IL-4, IL-5, and IL-13, which are important in humoral immunity and protection …
cells produce IL-4, IL-5, and IL-13, which are important in humoral immunity and protection …
MTF2 recruits Polycomb Repressive Complex 2 by helical-shape-selective DNA binding
Polycomb-mediated repression of gene expression is essential for development, with a
pivotal role played by trimethylation of histone H3 lysine 27 (H3K27me3), which is deposited …
pivotal role played by trimethylation of histone H3 lysine 27 (H3K27me3), which is deposited …
Molecular architecture of polycomb repressive complexes
EC Chittock, S Latwiel, TCR Miller… - Biochemical Society …, 2017 - portlandpress.com
The polycomb group (PcG) proteins are a large and diverse family that epigenetically
repress the transcription of key developmental genes. They form three broad groups of …
repress the transcription of key developmental genes. They form three broad groups of …
Engaging chromatin: PRC2 structure meets function
Abstract Polycomb repressive complex 2 (PRC2) is a key epigenetic multiprotein complex
involved in the regulation of gene expression in metazoans. PRC2 is formed by a tetrameric …
involved in the regulation of gene expression in metazoans. PRC2 is formed by a tetrameric …
An RB-EZH2 complex mediates silencing of repetitive DNA sequences
Repetitive genomic regions include tandem sequence repeats and interspersed repeats,
such as endogenous retroviruses and LINE-1 elements. Repressive heterochromatin …
such as endogenous retroviruses and LINE-1 elements. Repressive heterochromatin …
BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome
NA Fursova, AH Turberfield, NP Blackledge… - Genes & …, 2021 - genesdev.cshlp.org
Histone-modifying systems play fundamental roles in gene regulation and the development
of multicellular organisms. Histone modifications that are enriched at gene regulatory …
of multicellular organisms. Histone modifications that are enriched at gene regulatory …
PRC2, chromatin regulation, and human disease: insights from molecular structure and function
X Liu, X Liu - Frontiers in Oncology, 2022 - frontiersin.org
Polycomb repressive complex 2 (PRC2) is a multisubunit histone-modifying enzyme
complex that mediates methylation of histone H3 lysine 27 (H3K27). Trimethylated H3K27 …
complex that mediates methylation of histone H3 lysine 27 (H3K27). Trimethylated H3K27 …
Post-translational modifications of PRC2: signals directing its activity
Abstract Polycomb repressive complex 2 (PRC2) is a chromatin-modifying enzyme that
catalyses the methylation of histone H3 at lysine 27 (H3K27me1/2/3). This complex …
catalyses the methylation of histone H3 at lysine 27 (H3K27me1/2/3). This complex …